Extended Data Fig. 9: Cholesterol metabolic dysregulation in HBV-related early-stage HCC. | Nature

Extended Data Fig. 9: Cholesterol metabolic dysregulation in HBV-related early-stage HCC.

From: Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

Extended Data Fig. 9

a, Representative immunohistochemical staining of TMA with SOAT1 antibodies in an independent cohort of HCC (n = 254, biologically independent samples). Scale bars, 50 μm. b, Staining intensity of SOAT1 between non-tumour (N) and tumour (T) samples from TMA (n = 254). Data are mean ± s.d. c, Intensities of three cholesteryl esters in paired non-tumour and tumour HCC samples (n = 25) by electrospray ionization mass spectrometry. In the box plots, the middle bar represents the median, and the box represents the interquartile range; bars extend to 1.5× the interquartile range. d, e, Upregulation of the cholesterol-metabolism-related proteins (d) or their mRNAs (e) in paired non-tumour and tumour samples. The black lines in the middle of the plots indicate the mean of protein intensities (± s.e.m.) and mRNA abundance (± s.e.m.). The P values are calculated by two-sided Wilcoxon rank-sum test (be).

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