Extended Data Fig. 8: Signature proteins in S-III tumours and the association of proteomic subtypes with genomic mutations and established transcriptomic signatures of HCC classifications. | Nature

Extended Data Fig. 8: Signature proteins in S-III tumours and the association of proteomic subtypes with genomic mutations and established transcriptomic signatures of HCC classifications.

From: Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

Extended Data Fig. 8

a, Global heat map of the relative abundance of the signature proteins in the S-III tumours. Biological functions related to these proteins are denoted by the colour panel on the right, and annotated according to the pathways based on enrichment of MSigDB ontologies. b, Association of the proteomic subtypes with p53 and CTNNB1 mutations, and mRNA-based HCC subclasses. Samples with positive results are coloured in red, and the negative samples are shown in grey. Samples with no statistical significance, or which are not available, are coloured in white. The immunosuppression subclass is labelled by the dashed box. Prediction of mRNA-based HCC subclasses and immune-cell types was performed using nearest template prediction analysis, and ssGSEA and model-based clustering analysis, respectively (Methods). c, Immune infiltration in proteomic subtypes. Samples with high immune infiltration are coloured in red and samples with low immune infiltration are coloured in grey. P values are calculated by one-sided Fisher’s exact test.

Source data