Extended Data Fig. 5: Freezing behaviour and correlation with MD activity during fear extinction. | Nature

Extended Data Fig. 5: Freezing behaviour and correlation with MD activity during fear extinction.

From: Neural circuits underlying a psychotherapeutic regimen for fear disorders

Extended Data Fig. 5

a, b, Fear extinction (a) and subsequent retention tests (b) with MD single-unit recordings (CS, n = 6; ABS + CS, n = 8 mice). Mixed-design ANOVA for extinction: F1,12 = 13.85, P = 0.000292 for group effect. Mixed-design ANOVA for retention tests: F1,12 = 33.1, P = 9.11 × 10−5 for group effect. Mean ± s.e.m.; post hoc multiple comparison with Bonferroni correction; **P < 0.01, ***P < 0.001. cf, Pearson’s correlation analyses of MD positive responses (CS, n = 6; ABS + CS, n = 8 mice) during fear extinction with freezing during late extinction trials (c, a block of the last three extinction trials), recall test (d), spontaneous recovery test (e) or renewal test (f). gj, Pearson’s correlation analyses of MD negative responses (CS, n = 4; ABS + CS, n = 8 mice) during fear extinction with freezing during late extinction trials (g), recall test (h), spontaneous recovery test (i) or renewal test (j). See Supplementary Table 1 for statistical details.