Extended Data Fig. 3: Freezing behaviour and correlation with SC activity during fear extinction. | Nature

Extended Data Fig. 3: Freezing behaviour and correlation with SC activity during fear extinction.

From: Neural circuits underlying a psychotherapeutic regimen for fear disorders

Extended Data Fig. 3

a, b, Fear extinction (a) and subsequent retention tests (b) with SC single-unit recordings (CS, n = 10; ABS + CS, n = 8 mice). Mixed-design ANOVA for extinction: F1,16 = 29.73, P = 5.32 × 10−5 for group effect. Mixed-design ANOVA for retention tests: F1,16 = 32.65, P = 3.2 × 10−5 for group effect. Mean ± s.e.m.; post hoc multiple comparison with Bonferroni correction; *P < 0.05, **P < 0.01, ***P < 0.001. Asterisks above bars indicate significant difference in comparison to recall. cf, Pearson’s correlation analyses of SC positive responses (CS, n = 9; ABS + CS, n = 8 mice) during fear extinction with freezing during late extinction trials (c; a block of the last three extinction trials), recall test (d), spontaneous recovery test (e) or renewal test (f). gj, Pearson’s correlation analyses of SC negative responses (CS, n = 5; ABS + CS, n = 5 mice) during fear extinction with freezing during late extinction trials (g), recall test (h), spontaneous recovery test (i) or renewal test (j). See Supplementary Table 1 for statistical details.