Extended Data Fig. 1: Effect of ABS pairing on fear extinction of strong fear memory and effect on memory reactivation and reconsolidation. | Nature

Extended Data Fig. 1: Effect of ABS pairing on fear extinction of strong fear memory and effect on memory reactivation and reconsolidation.

From: Neural circuits underlying a psychotherapeutic regimen for fear disorders

Extended Data Fig. 1

a, One day after fear conditioning (0.7 mA foot shock), visual stimulation was presented during fear extinction (n = 7 mice for each group). Mixed-design ANOVA for extinction: F4,30 = 78.62, P = 1.85 × 10−15 for group effect. One-way ANOVA for recall test: F4,30 = 53.95, P = 2.81 × 10−13. b, Effects of ABS pairing on fear relapse (n = 7 mice for each group). Two-way ANOVA: F1,36 = 138.521, P = 6.73 × 10−14 for group effect. Post hoc multiple comparison with Bonferroni correction; ***P < 0.001. Asterisks above bars indicate significant difference in comparison to recall. c, Effects of ABS pairing during memory reactivation (CS, n = 8; ABS + CS, n = 8 mice). Student’s t-test, two-sided: t(14) = −3.9058, P = 0.001584 for memory reactivation; t(14) = 0.2411, P = 0.813 for PR-LTM; **P < 0.01. Data shown as mean ± s.e.m. See Supplementary Table 1 for statistical details.