Extended Data Fig. 9: Freezing behaviour and correlation with BLA activity during fear extinction. | Nature

Extended Data Fig. 9: Freezing behaviour and correlation with BLA activity during fear extinction.

From: Neural circuits underlying a psychotherapeutic regimen for fear disorders

Extended Data Fig. 9

a, b, Fear extinction (a) and subsequent retention tests (b) with BLA single-unit recordings (CS, n = 8; ABS + CS, n = 9 mice). Mixed-design ANOVA for extinction: F1,15 = 19.46, P = 0.000505 for group effect. Mixed-design ANOVA for retention tests: F1,15 = 27.29, P = 0.000103 for group effect. Mean ± s.e.m.; post hoc multiple comparison with Bonferroni correction; **P < 0.01, ***P < 0.001. cf, Pearson’s correlation analyses of fear-cell trial responses (CS, n = 8; ABS + CS, n = 9 mice) with freezing during late extinction trials (c; a block of the last three extinction trials), recall test (d), spontaneous recovery test (e) or renewal test (f). gj, Pearson’s correlation analyses of resistant-cell trial responses (CS, n = 7; ABS + CS, n = 7 mice) with freezing during late extinction trials (g), recall test (h), spontaneous recovery test (i) or renewal test (j). kn, Pearson’s correlation analyses of extinction-cell trial responses (CS, n = 8; ABS + CS, n = 7 mice) with freezing during late extinction trials (k), recall test (l), spontaneous recovery test (m) or renewal test (n). See Supplementary Table 1 for statistical details.

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