Extended Data Fig. 10: Distribution of SznF homologues in microbial genomes. | Nature

Extended Data Fig. 10: Distribution of SznF homologues in microbial genomes.

From: An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

Extended Data Fig. 10

a, Maximum-likelihood phylogenetic tree inferred from 50 replicates showing the relationship between selected SznF homologues containing both the central domain and cupin domain (NCBI Non-Redundant Protein Sequences database, 2018) (E <1 × 10−50). The branch corresponding to S. achromogenes SznF is highlighted by a single asterisk. Bootstrap confidence values of >50 are indicated by black circles on the nodes. The amino acid sequence of UndA is used as an outgroup (highlighted as ). The sequences used to generate this tree are tabulated in Supplementary Table 2. b, Distribution of 352 SznF homologues that contain both a central domain and a cupin domain in different bacterial genera (IMG/JGI ‘all isolates’ database, 2018) (E <1 × 10−5). See also Supplementary Table 3. c, Selected biosynthetic gene clusters that encode homologues of SznF.

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