Extended Data Fig. 2: Robustness of inference to cell numbers and technical noise in scRNA-seq. | Nature

Extended Data Fig. 2: Robustness of inference to cell numbers and technical noise in scRNA-seq.

From: Genomic encoding of transcriptional burst kinetics

Extended Data Fig. 2

aj, The distribution of inferred burst frequency and sizes as a function of sensitivity (loss of RNA molecules) and cell numbers, based on the location of the parameters in the kinetics parameter space. Centre lines denote the median; hinges denote the first and third quartiles; whiskers denote 1.5× the interquartile range (IQR). Distributions are based on 50 simulations for each unique combination of parameters and 100 cells for the sensitivity calculations. Inferred burst sizes were divided by the sensitivity used in simulation (as the inferred burst size scales linearly with sensitivity).

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