Extended Data Fig. 2: Immune response is not involved in decreased tumour growth observed in Atg7Δ/Δ hosts. | Nature

Extended Data Fig. 2: Immune response is not involved in decreased tumour growth observed in Atg7Δ/Δ hosts.

From: Autophagy maintains tumour growth through circulating arginine

Extended Data Fig. 2

ac, Comparison of tumour weight between Atg7+/+ (n = 5) and Atg7Δ/Δ (a, n = 5; c, n = 6) hosts after injection of 1.7 (a) or 1.9 (c) cells. Data are mean ± s.e.m. b, d, Immunohistochemistry quantification of Ki-67+ and active caspase-3+ in 1.7 (b) and 1.9 (d) tumours from Atg7+/+ and Atg7Δ/Δ hosts. Data are mean ± s.e.m. e, Representative immunohistochemistry images and quantification of CD3+, CD4+ and CD8+ cells in tumours from Atg7+/+ and Atg7Δ/Δ hosts. Data are mean ± s.e.m. f, Comparison of tumour volume and weight between Atg7+/+ (n = 10), Atg7+/+ + CD4 and CD8 antibody depletion (n = 15), Atg7Δ/Δ (n = 7) and Atg7Δ/Δ + CD4 and CD8 antibody depletion (n = 8) hosts. Data are mean ± s.e.m. *P < 0.05, ****P < 0.0001. g, Fold change in immune components between Atg7+/+ and Atg7Δ/Δ, with or without antibody depletion (n = 5 each). Treg, T regulatory cells; DC, dendritic cells; MDSC, myeloid-derived suppressor cells. Data are mean ± s.e.m. ***P < 0.001, ****P < 0.0001, by two-way ANOVA test.

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