Extended Data Fig. 8: Dietary arginine supplementation rescues YUMM 1.3 tumour growth in Atg7Δ/Δ hosts. | Nature

Extended Data Fig. 8: Dietary arginine supplementation rescues YUMM 1.3 tumour growth in Atg7Δ/Δ hosts.

From: Autophagy maintains tumour growth through circulating arginine

Extended Data Fig. 8

a, Serum arginine, ornithine and citrulline in Atg7+/+ (n = 5), Atg7+/+ + 1% arginine (n = 5), Atg7Δ/Δ (n = 6) and Atg7Δ/Δ + 1% arginine (n = 6) hosts, obtained by LC–MS. Data are mean ± s.e.m. *P < 0.05, **P < 0.01. b, Comparison of YUMM 1.3 tumour weight between Atg7+/+ and Atg7Δ/Δ (n = 5 each) hosts, with or without arginine supplementation. Data are mean ± s.e.m. **P < 0.01, ****P < 0.0001. c, Immunohistochemistry quantification of Ki-67+ and active caspase-3+ cells in tumours from Atg7+/+ and Atg7Δ/Δ hosts, with or without arginine supplementation. Data are mean ± s.e.m. **P < 0.01, ****P < 0.0001.

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