Extended Data Fig. 6: TDP-43 binds to mRNAs that encode sarcomeric proteins during muscle formation. | Nature

Extended Data Fig. 6: TDP-43 binds to mRNAs that encode sarcomeric proteins during muscle formation.

From: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

Extended Data Fig. 6

Related to Fig. 3. a, Myoblast (left), myotube (middle) and shared (right) connectome analysis for all TDP-43 eCLIP peaks (top) and TDP-43 exonic peaks (bottom). b, TDP-43 binds predominantly to exons of protein-coding RNAs in C2C12 myoblasts. c, Peak distribution for significantly enriched TDP-43 peak locations in myoblasts and myotubes across the transcriptome reveal increased exonic and 3′-UTR associations compared to previously identified neuronal TDP-43 peaks18,19. d, Identification of multiple TDP-43-binding sites across and within exons of Ttn. The zoomed region is representative of multiple UG-rich sequences within a single exon. n = 3 biologically independent experiments, each showing similar results.

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