Extended Data Fig. 3: cGAS translocates to the nucleus in response to DNA damage independently of its DNA-binding ability or enzymatic activity. | Nature

Extended Data Fig. 3: cGAS translocates to the nucleus in response to DNA damage independently of its DNA-binding ability or enzymatic activity.

From: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

Extended Data Fig. 3

a, Immunofluorescence assay results showing localization of transfected HA–cGAS and corresponding mutants (anti-HA, green) in PC-9 cells exposed to etoposide (100 μg ml−1) for 4 h. Data represent n = 3 independent experiments. Quantitative data are depicted in b. At least 100 transfected cells were counted in each experiment. Data are expressed as mean ± s.e.m. of n = 3 independent experiments. One-way ANOVA was used for statistical analysis. NS, not significant.