Extended Data Fig. 7: Environmental covariates significantly associated with the microbiome profiles. | Nature

Extended Data Fig. 7: Environmental covariates significantly associated with the microbiome profiles.

From: Temporal development of the gut microbiome in early childhood from the TEDDY study

Extended Data Fig. 7

16S rRNA gene sequencing data plotted from months 3–40 of life (n = 11,717). Curves show LOESS fit for the data per category, and shaded areas show permutation-based 95% confidence intervals for the fit. Significance determined by linear mixed-effects models in accordance with observed phases of maturation: developmental (months 3–14), transitional (months 15–30), and stable (months 31–46). Shaded lines represent the ±95% confidence interval. Longitudinal development of the Shannon’s diversity index, microbiota age and MAZ score by geographical location (ac), occurrence of household siblings (df), and occurrence of household furry pets (gi).

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