Extended Data Fig. 6: Comparison of fine-mapping in GIANT (2014) and UK Biobank imputed data. | Nature

Extended Data Fig. 6: Comparison of fine-mapping in GIANT (2014) and UK Biobank imputed data.

From: The UK Biobank resource with deep phenotyping and genomic data

Extended Data Fig. 6

Here we summarize results of our credible set analysis in GIANT (2014) and UK Biobank for 575 genomics regions associated with standing height in both studies (see Methods). A red solid line on a plot indicates where x = y. a, Both plots compare the number of markers in the 95% credible sets in which the size is less than 18 markers in both studies (363 regions in the left-hand plot; 445 in the right-hand plot). b, c, Both plots are from the analysis considering all markers in each study. In b we show, for each region, the proportion of markers used in the analysis for a given study that are in the 95% credible set for that study. The plot contains the same 363 regions as shown in the left-hand plot in a. In c we summarize, for all 575 regions, how much weight our UK Biobank analysis placed on markers that our analysis of GIANT (2014) indicated were important.

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