a, Time-kill data of E. coli ATCC 25922 when treated with G0775 at 0.25, 1, 4 and 16 times the measured MIC of 0.125 µg ml−1. The data is an average of three independent experiments with error bars representing s.d. b, Western blot of V5-epitope-tagged LepB from an arabinose-inducible conditional LepB strain (E. coli UPEC CFT073) grown in the indicated sugar concentrations. This experiment was performed once. c, Growth-curve analysis of the same conditional LepB strain grown in the indicated sugar concentrations. Data is an average of triplicate data points with error bars representing s.d. The graph is a representative of three independent experiments.