Extended Data Fig. 1: Ligand-gated signalling of A. bakeri and A. gambiae Orcos. | Nature

Extended Data Fig. 1: Ligand-gated signalling of A. bakeri and A. gambiae Orcos.

From: Cryo-EM structure of the insect olfactory receptor Orco

Extended Data Fig. 1

a, Fluorescence changes in HEK293 cells transfected with a genetically encoded Ca2+ indicator, GCaMP6s, and Orco from A. bakeri (Abak; closed circles) or A. gambiae (Agam; open circles) alone, or with an A. gambiae OR. Dose–response curves were obtained by titrating with VUAA1 or the cognate odour of the OR. b, Average fitted Hill equation parameters from N number of independent replicates. EC50 is the concentration for half-maximal response and n is the Hill coefficient (both mean ± s.d.). 245-T is 2,4,5-trimethylthiazole.