Extended Data Fig. 5: Potential extracellular facing odour-binding pocket. | Nature

Extended Data Fig. 5: Potential extracellular facing odour-binding pocket.

From: Cryo-EM structure of the insect olfactory receptor Orco

Extended Data Fig. 5

a, Side view of Orco highlighting the location of residues in Orco or ORs that, when mutated, alter ligand-binding specificity. Orco residues that are equivalent to point mutations that alter odour specificity in Helicoverpa assaulta OR14b24, A. gambiae OR1525, D. melanogaster OR85b26 or Ostrinia furnacalis OR327 are shown as red spheres. Residues required for VUAA1 sensitivity in Orco23 are shown as blue spheres. In Orco, the S3–S4 extracellular loop is positioned above the pocket. b, A 15 Å cross-section through the pocket from a.