Review Article | Published:

Challenges and recent progress in drug discovery for tropical diseases

Naturevolume 559pages498506 (2018) | Download Citation

Abstract

Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.

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Acknowledgements

We acknowledge the following organizations that have supported our drug-discovery efforts for some of these diseases: Wellcome Trust, Medicines for Malaria Venture, the Bill and Melinda Gates Foundation and Drugs for Neglected Diseases initiative. We thank members of the Drug Discovery Unit for helpful discussions and K. Read, S. Green and S. Wyllie for reading the manuscript.

Reviewer information

Nature thanks B. Melillo, E. Winzeler and the other anonymous reviewer(s) for their contribution to the peer review of this work.

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Affiliations

  1. Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK

    • Manu De Rycker
    • , Beatriz Baragaña
    •  & Ian H. Gilbert
  2. Medicines Monitoring Unit (MEMO), Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK

    • Suzanne L. Duce

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All the authors contributed to writing the text.

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The authors declare no competing interests.

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Correspondence to Ian H. Gilbert.

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https://doi.org/10.1038/s41586-018-0327-4

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