Extended Data Fig. 6: Protein abundance does not change during the formation of mitotic granules upon GSK-626616 inhibitor treatment. | Nature

Extended Data Fig. 6: Protein abundance does not change during the formation of mitotic granules upon GSK-626616 inhibitor treatment.

From: Kinase-controlled phase transition of membraneless organelles in mitosis

Extended Data Fig. 6

a, Time-lapse images (single Z-stack) show fusion of mitotic SRRM2–mCherry granules formed in the presence of the GSK-626616 inhibitor (1 μM) in cells arrested in mitosis (thymidine–nocodazole block). b, Mean cell intensity of SRRM2–mCherry is plotted during mitotic granule formation on addition of GSK-626616 inhibitor (1 μM). Data are mean ± s.d. c, Top, mean intensity of SRRM2–mCherry in the dissolved phase is plotted during mitotic granule formation on addition of GSK-626616 inhibitor (1 μM). Bottom, time-lapse images of the cells plotted in the top panel. Images are representative of at least three independent experiments. Scale bars, 10 μm.

Source Data