Extended Data Fig. 6: Chemogenetic silencing of neurons in the taste cortex impairs tastant recognition. | Nature

Extended Data Fig. 6: Chemogenetic silencing of neurons in the taste cortex impairs tastant recognition.

From: The coding of valence and identity in the mammalian taste system

Extended Data Fig. 6

a, Quantification of the error rate for sweet taste recognition (2 mM AceK) in a three-port assay before and after silencing neurons in the sweet taste cortex with inhibitory DREADD (hM4Di) and CNO (10 mg kg−1). n = 5 mice, repeated-measures one-way ANOVA followed by Bonferroni post hoc test, F2,8 = 46.84, P < 0.0001. Pharmacological silencing data using NBQX can be found in a previously published study7. b, Quantification of the error rate of sweet taste recognition (1 mM AceK) before and after silencing of the amygdala with inhibitory DREADD (hM4Di) and CNO (10 mg kg−1). n = 4 mice, two-tailed paired t-test; pre versus CNO, P = 0.7888. See also Fig. 6. Note that sweet recognition was only affected by silencing the taste cortex, but not the amygdala. All tested animals recognized sweet taste with the correct behavioural choice (before silencing) in at least 90% of the trials. Values are mean ± s.e.m. See Supplementary Table 1 for detailed statistics.

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