Extended Data Fig. 4: Activation of bitter cortical projections to posterior BLA is aversive. | Nature

Extended Data Fig. 4: Activation of bitter cortical projections to posterior BLA is aversive.

From: The coding of valence and identity in the mammalian taste system

Extended Data Fig. 4

As shown in Fig. 1 and Extended Data Fig. 1, a fraction of the bitter cortico-amygdalar projections terminate in the posterior BLA. As expected, stimulation of these projections elicits aversive responses. a, Representative histograms showing licking events in the presence (blue) or absence (grey) of photostimulation of bitter cortical projections to the posterior BLA. AAV-ChR2 was injected into the bitter cortex, and the stimulating fibre was targeted above the posterior BLA (coordinates: bregma −2 mm; lateral 3.4 mm; ventral 4.3 mm). b, Quantification of licking responses. n = 3 mice, two-tailed paired t-test, P = 0.0121. Values are mean ± s.e.m.

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