a, Distribution of ploidy and fraction of heterozygous isolates. b, Violin plot of growth fitness trait by ploidy. Diploid isolates are globally fitter than individuals with other ploidy levels. Number of trait values for 1n isolates = 4,585; for 2n isolates = 26,249; for 3n isolates = 1,610; and for 4n isolates = 1,330. c, Distribution of aneuploid chromosomes per individual. d, Violin plot of growth fitness trait of aneuploid (n = 6,510) and euploid (n = 20,719) isolates shows a significant difference in fitness trait between the two categories. All P values were calculated using a two-sided Mann–Whitney–Wilcoxon test. Centre lines, median; boxes, interquartile range (IQR); whiskers, 1.5 × IQR. Data points beyond the whiskers are outliers.