Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Prostate cancer

Intralesional heterogeneity on PSMA PET–CT predicts mCRPC outcomes

Nature Reviews Urology volume 21, page 577 (2024)Cite this article

Subjects

Intra-tumour heterogeneity in patients with metastatic castration-resistant prostate cancer (mCRPC) poses a challenge to treatment, owing to variability in tumour growth and response to therapy. Currently available tools such as response evaluation criteria in solid tumors (RECIST) and circulating tumour DNA (ctDNA) are useful methods to measure patient response to treatment but do not enable the assessment of individual tumour lesions with high resolution.

In a new study published in Med, the potential of 68Ga-prostate-specific membrane antigen (PSMA) + 18F-fluorodeoxyglucose (FDG) paired positron emission tomography–computed tomography (PET–CT) was assessed to capture intralesional response heterogeneity (ILRH) and improve risk stratification in patients with mCRPC.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Maria Chiara Masone

Authors
  1. Maria Chiara Masone
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maria Chiara Masone.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Masone, M.C. Intralesional heterogeneity on PSMA PET–CT predicts mCRPC outcomes. Nat Rev Urol 21, 577 (2024). https://doi.org/10.1038/s41585-024-00943-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41585-024-00943-2

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer