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The interplay between male fertility, mental health and sexual function

Nature Reviews Urology (2024)Cite this article

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Declining birth rates are drawing attention to male reproductive health, with infertility receiving overdue interest. Alongside genetic and environmental factors, lifestyle behaviours are a key risk factor. Exploring how lifestyle behaviour links to mental health and its interplay with sexual function and fertility can improve understanding of trends in live births and improve men’s health overall.

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Fig. 1: The interplay between male fertility, mental health and sexual function.

References

  1. GBD 2021 Fertility and Forecasting Collaborators. Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. Lancet 403, 2057–2099 (2024).

  2. Eisenberg, M. L. et al. Male infertility. Nat. Rev. Dis. Primers 9, 49 (2023).

    Article  PubMed  Google Scholar 

  3. Kimmins, S. et al. Frequency, morbidity and equity — the case for increased research on male fertility. Nat. Rev. Urol. 21, 102–124 (2024).

    Article  PubMed  Google Scholar 

  4. Skakkebæk, N. E. et al. Environmental factors in declining human fertility. Nat. Rev. Endocrinol. 18, 139–157 (2022).

    Article  PubMed  Google Scholar 

  5. Liu, A. et al. Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women. Nat. Hum. Behav. 8, 276–287 (2024).

    Article  PubMed  Google Scholar 

  6. Platt, M. L. & Sterling, P. Declining human fertility and the epidemic of despair. Nat. Mental Health 2, 463–465 (2024).

    Article  Google Scholar 

  7. Belladelli, F., Muncey, W. & Eisenberg, M. L. Reproduction as a window for health in men. Fertil. Steril. 120, 429–437 (2023).

    Article  PubMed  Google Scholar 

  8. Herrera-Luis, E., Benke, K., Volk, H., Ladd-Acosta, C. & Wojcik, G. L. Gene–environment interactions in human health. Nat. Rev. Genet. https://doi.org/10.1038/s41576-024-00731-z (2024).

  9. Nargund, V. H. Effects of psychological stress on male fertility. Nat. Rev. Urol. 12, 373–382 (2015).

    Article  PubMed  CAS  Google Scholar 

  10. Vandello, J. A., Wilkerson, M., Bosson, J. K., Wiernik, B. M. & Kosakowska-Berezecka, N. Precarious manhood and men’s physical health around the world. Psychol. Men Masc. 24, 1–15 (2023).

    Google Scholar 

  11. Lo, J. O. et al. Influence of substance use on male reproductive health and offspring outcomes. Nat. Rev. Urol. https://doi.org/10.1038/s41585-024-00868-w (2024).

  12. Benónísdóttir, S., Straub, V. J., Kong, A. & Mills, M. C. Genetics of 44 female and male reproductive traits and their relationship with health, longevity and consequences for offspring. Nat. Aging (in the press).

  13. Straub, V. Letter: declining birth rates are a symptom of a male malaise. Financial Times (26 February 2024).

  14. White, A. & Tod, M. The need for a strategy on men’s health. Trends Urol. Mens Health 13, 2–8 (2022).

    Article  Google Scholar 

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Acknowledgements

V.J.S. and M.C.M. are supported by ESSGN (HORIZON - MSCA - DN - 2021 (101073237)) and the Leverhulme Trust Large Centre Grant LCDS (RC - 2018 – 003). M.C.M. is additionally supported by ESRC/UKRI Connecting Generations (ES/W002116/1), an ERC Advanced Grant (835079), EU MapIneq (202061645) and Einstein Foundation Berlin (EZ - 2019 - 555 - 2).

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Authors and Affiliations

  1. Leverhulme Centre for Demographic Science, Nuffield Department of Population Health, University of Oxford, Oxford, UK

    Vincent J. Straub & Melinda C. Mills

  2. Department of Economics, Econometrics & Finance, University of Groningen, Groningen, the Netherlands

    Melinda C. Mills

  3. Nuffield College, University of Oxford, Oxford, UK

    Melinda C. Mills

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  1. Vincent J. Straub
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  2. Melinda C. Mills
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Correspondence to Vincent J. Straub.

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Competing interests

M.C.M. is a Trustee of the UK Biobank, on the Scientific Advisory Boards of Our Future Health and Lifelines Biobank and on the Data Management Advisory Board of the Health and Retirement Survey. V.J.S. declares no competing interests.

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Straub, V.J., Mills, M.C. The interplay between male fertility, mental health and sexual function. Nat Rev Urol (2024). https://doi.org/10.1038/s41585-024-00936-1

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