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Sexual medicine

Doxycycline-PEP — novel and promising but needs monitoring

Sexually transmitted infections (STIs) remain public health concerns. Doxycycline post-exposure prophylaxis to prevent STIs is a novel promising intervention, which in a new study caused an 65% reduction in incident STIs. However, long-term effects on STI prevalence, microbiomes and antimicrobial resistance among STI pathogens, non-STI pathogens and commensals need to be monitored.

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Work at the WHO Collaborating Centre for Gonorrhoea and Other STIs is supported by grants to M.U. from, for example, the Örebro County Council Research Committee; the Foundation for Medical Research at Örebro University Hospital, Örebro, Sweden; the Global Antibiotic Research and Development Partnership (GARDP); the European Centre for Disease Prevention and Control; and WHO. F.Y.S.K. is supported by a University of Melbourne Faculty C.R. Roper Fellowship.

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Correspondence to Magnus Unemo.

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Unemo, M., Kong, F.Y.S. Doxycycline-PEP — novel and promising but needs monitoring. Nat Rev Urol 20, 522–523 (2023).

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