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Urothelial carcinoma

The prognostic role of stroma in UTUC

Nature Reviews Urology volume 20, page 7 (2023)Cite this article

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In the multicentre, real world study TSU-01 published in the British Journal of Cancer, the prognostic and predictive value of the tumour:stroma ratio (TSR) were assessed in 1,015 patients who underwent radical nephroureterectomy for upper tract urothelial carcinoma (UTUC). Patients with stroma-high tumours (>50% stroma) had poorer survival outcomes (overall survival and cancer-specific survival) than patients with low-stroma UTUC (<50% stroma). High stroma was also associated with a decreased response to chemotherapy. The authors established a TSR-based nomogram that could be integrated into the decision-making process for the treatment of patients with UTUC.

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  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Maria Chiara Masone

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  1. Maria Chiara Masone
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Correspondence to Maria Chiara Masone.

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Masone, M.C. The prognostic role of stroma in UTUC. Nat Rev Urol 20, 7 (2023). https://doi.org/10.1038/s41585-022-00698-8

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  • DOI: https://doi.org/10.1038/s41585-022-00698-8

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