Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Clinical Outlook
  • Published:

Partial gland cryoablation for prostate cancer — where are we?

Nature Reviews Urology volume 20, pages 127–128 (2023)Cite this article

Subjects

The treatment landscape for localized prostate cancer is rapidly evolving to achieve oncological disease control, simultaneously preserving gastrointestinal and genitourinary function. Focal therapy using cryoablation is an emerging treatment for prostate cancer. Short-term and intermediate-term clinical data on focal cryoablation therapy in prostate cancer have shown promising oncological and functional outcomes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Partial gland cryoablation of the prostate.

References

  1. Das, K., Benzil, D. L., Rovit, R. L., Murali, R. & Couldwell, W. T. Irving S. Cooper (1922-1985): a pioneer in functional neurosurgery. J. Neurosurg. 89, 865–873 (1998).

    Article  CAS  PubMed  Google Scholar 

  2. Gonder, M. J., Soanes, W. A. & Shulman, S. Cryosurgical treatment of the prostate. Invest. Urol. 3, 372–378 (1966).

    CAS  PubMed  Google Scholar 

  3. Donnelly, B. J. et al. A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer. Cancer 116, 323–330 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Tan, W. P. et al. Oncological and functional outcomes of men undergoing primary whole gland cryoablation of the prostate: a 20-year experience. Cancer https://doi.org/10.1002/cncr.34458 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kenigsberg, A. P. et al. The use of magnetic resonance imaging to predict oncological control among candidates for focal ablation of prostate cancer. Urology 112, 121–125 (2018).

    Article  PubMed  Google Scholar 

  6. Wysock, J. S., Becher, E., Gogaj, R., Velazquez, N. & Lepor, H. Early oncological control following partial gland cryo-ablation: a prospective experience specifying reflex MRI guided biopsy of the ablation zone. Prostate Cancer Prostatic Dis. 24, 114–119 (2021).

    Article  PubMed  Google Scholar 

  7. Tan, W. P., Chang, A., Sze, C. & Polascik, T. J. Oncological and functional outcomes of patients undergoing individualized partial gland cryoablation of the prostate: a single-institution experience. J. Endourol. 35, 1290–1299 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Thakker, S., Wysock, J., Matulewicz, R., Gogaj, R. & Lepor, H. Early functional outcomes following partial gland cryo-ablation. Can. J. Urol. 29, 11128–11135 (2022).

    PubMed  Google Scholar 

  9. Taha, T. et al. Does the type of cryoprobe affect oncological and functional outcomes in men with clinically localized prostate cancer treated with primary whole gland prostate cryoablation? Curr. Urol. 15, 79–84 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Lebastchi, A. H. et al. Standardized nomenclature and surveillance methodologies after focal therapy and partial gland ablation for localized prostate cancer: an international multidisciplinary consensus. Eur. Urol. 78, 371–378 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, NYU Langone Health, New York, NY, USA

    Wei Phin Tan, James S. Wysock & Herbert Lepor

Authors
  1. Wei Phin Tan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James S. Wysock
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Herbert Lepor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wei Phin Tan.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Related links

Galil Medical: https://www.bostonscientific.com/en-US/products/cryoablation.html

Healthtronics: https://www.healthtronics.com/

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tan, W.P., Wysock, J.S. & Lepor, H. Partial gland cryoablation for prostate cancer — where are we?. Nat Rev Urol 20, 127–128 (2023). https://doi.org/10.1038/s41585-022-00685-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41585-022-00685-z

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing