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Race and prostate cancer: genomic landscape

Nature Reviews Urology volume 19, pages 547–561 (2022)Cite this article

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Abstract

In the past 20 years, new insights into the genomic pathogenesis of prostate cancer have been provided. Large-scale integrative genomics approaches enabled researchers to characterize the genetic and epigenetic landscape of prostate cancer and to define different molecular subclasses based on the combination of genetic alterations, gene expression patterns and methylation profiles. Several molecular drivers of prostate cancer have been identified, some of which are different in men of different races. However, the extent to which genomics can explain racial disparities in prostate cancer outcomes is unclear. Future collaborative genomic studies overcoming the underrepresentation of non-white patients and other minority populations are essential.

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Fig. 1: Prevalence of genomic alterations in patients with primary prostate cancer stratified according to self-reported race.

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Author notes

  1. These authors contributed equally: Camilo Arenas-Gallo, Jude Owiredu.

Authors and Affiliations

  1. Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Camilo Arenas-Gallo, Ilon Weinstein & Jonathan E. Shoag

  2. Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA

    Jude Owiredu, Patrick Lewicki, Spyridon P. Basourakos, Bashir Al Hussein Al Awamlh, Christopher E. Barbieri & Jonathan E. Shoag

  3. Department of Urology, University of Michigan, Ann Arbor, MI, USA

    Randy Vince Jr

  4. Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA

    Bashir Al Hussein Al Awamlh

  5. Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Fredrick R. Schumacher

  6. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

    Fredrick R. Schumacher & Jonathan E. Shoag

  7. Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Daniel E. Spratt

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Contributions

C.A.G., J.O., I.W., P.L., S.P.B., B.A.H.A.A., F.R.S., D.E.S., C.B. and J.E.S. researched data for the article. All authors contributed substantially to discussion of the content. All authors wrote the article. All authors reviewed and/or edited the manuscript before submission.

Corresponding author

Correspondence to Jonathan E. Shoag.

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Competing interests

D.E.S. reports personal fees from Boston Scientific, AstraZeneca, Janssen, and Blue Earth. J.E.S. is supported by the Frederick J. and Theresa Dow Foundation of the New York Community Trust, Vinney Scholars Award and a Damon Runyon Cancer Research Foundation Physician-Scientist Training Award. F.R.S. is supported by NCI CA2333216, CA043703, CA241956 and CA254566. The other authors declare no competing interests.

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Arenas-Gallo, C., Owiredu, J., Weinstein, I. et al. Race and prostate cancer: genomic landscape. Nat Rev Urol 19, 547–561 (2022). https://doi.org/10.1038/s41585-022-00622-0

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