Estimation of post-surgery future glomerular filtration rate (fGFR) is crucial for the oncological management of patients with renal cell carcinoma or urinary tract urothelial carcinoma. A new and simple formula for calculating fGFR has been published and should be included in future guidelines for personalized treatment of patients to guide decisions on surgery, systemic therapies and optimal sequence of treatment.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Huang, W. C., Elkin, E. B., Levey, A. S., Lang, T. L. & Russo, P. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors — is there a difference in mortality and cardiovascular outcomes? J. Urol. 181, 55–62 (2009).
Wu, J. et al. Analysis of survival for patients with chronic kidney disease primarily related to renal cancer surgery. BJU Int. 121, 93–100 (2018).
Seisen, T. et al. Oncologic outcomes of kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma: a systematic review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel. Eur. Urol. 70, 1052–1068 (2016).
Birtle, A. et al. Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial. Lancet 395, 1268–1277 (2020).
Raman, J. D. et al. High rates of advanced disease, complications, and decline of renal function after radical nephroureterectomy. Urol. Oncol. https://doi.org/10.1016/j.urolonc.2013.06.015 (2014).
Ashley, C. & Dunleavy, A. (eds) The Renal Drug Handbook 5th edn (Taylor & Francis, 2019).
Lebacle, C. et al. Evaluation of axitinib to downstage cT2a renal tumours and allow partial nephrectomy: a phase II study. BJU Int. 123, 804–810 (2019).
Aguilar Palacios, D. et al. New baseline renal function after radical or partial nephrectomy: a simple and accurate predictive model. J. Urol. 205, 1310–1320 (2021).
Tafuri, A. et al. External validation of the Palacios’ equation: a simple and accurate tool to estimate the new baseline renal function after renal cancer surgery. World J. Urol. 40, 467–473 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Ferraris, F., Raman, J.D., Musso, C.G. et al. Measuring renal function before kidney surgery — evolving towards precision in medicine. Nat Rev Urol 19, 450–451 (2022). https://doi.org/10.1038/s41585-022-00613-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41585-022-00613-1