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BLADDER CANCER

CDH12-expressing cell population predicts patient response to therapy

Nature Reviews Urology volume 18, page 575 (2021)Cite this article

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A previously uncharacterized population of cells with an epithelial cell phenotype distinguished by high expression of cadherin 12 (CDH12), catenins and other epithelial markers has been discovered in high-grade muscle-invasive bladder cancer (MIBC). Patients with CDH12-enriched tumours had poor outcomes after receiving surgery with or without neoadjuvant chemotherapy, but outcomes were improved for patients who received immunotherapy. Thus, assessment of CDH12 enrichment could help in treatment decision-making for patients with MIBC.

“Neoadjuvant chemotherapy and immune checkpoint therapy have revolutionized bladder cancer management; however, determining which patients would benefit most from each type of therapy remains a major challenge,” says Dan Theodorescu, co-corresponding author of the paper, continuing “My hypothesis was that if we looked at the expression of individual cells within the tumour, we could define a second-generation bladder subtype architecture that would more effectively guide treatment and even perhaps find novel targets for therapies.”

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References

Original article

  • Gouin, K. H. III et al. An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer. Nat. Commun. 12, 4906 (2021)

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  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Louise Stone

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  1. Louise Stone
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Correspondence to Louise Stone.

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Stone, L. CDH12-expressing cell population predicts patient response to therapy. Nat Rev Urol 18, 575 (2021). https://doi.org/10.1038/s41585-021-00521-w

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  • DOI: https://doi.org/10.1038/s41585-021-00521-w

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