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Antibiotics impair immunotherapy for urothelial cancer

Nature Reviews Urology volume 17, pages 605–606 (2020)Cite this article

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Pooled clinical trial data reveal that antibiotics worsen progression-free survival and overall survival in patients with locally advanced and metastatic urothelial cancer receiving anti-PDL1 therapy. Consensus guidelines for antibiotic use in these patients, as well as diagnostic tools and corrective measures, are needed to decrease primary resistance to immune checkpoint inhibitors.

Refers to Hopkins, A. M., Kichenadasse, G., Karapetis, C. S., Rowland, A. & Sorich, M. J. Concomitant antibiotic use and survival in urothelial carcinoma treated with atezolizumab. Eur. Urol. https://doi.org/10.1016/j.eururo.2020.06.061 (2020).

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Fig. 1: Antibiotic use in patients receiving immune checkpoint inhibitors.

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Acknowledgements

L.Z. is supported by the Ligue contre le Cancer (équipe labellisée); Agence Nationale de la Recherche (ANR) – Projets blancs; Association pour la recherche sur le cancer (ARC) SIGN’IN; Cancéropôle Ile-de-France; Fondation pour la Recherche Médicale (FRM); a donation by Elior; Gustave Roussy Odyssea, the European Union Horizon 2020 Project Oncobiome; Fondation Carrefour; Institut National du Cancer (INCa); INSERM; Institut Universitaire de France; LabEx Immuno-Oncology (grant ANR-18-IDEX-0001); Recherche Hospitalo-Universitaire (RHU) Torino Lumière; the Seerave Foundation; and Site de Recherche Intégrée sur le Cancer (SIRIC) Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE).

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Authors and Affiliations

  1. Gustave Roussy Cancer Center, Villejuif, France

    Lisa Derosa & Laurence Zitvogel

  2. Université Paris Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France

    Lisa Derosa & Laurence Zitvogel

  3. INSERM U1015, Villejuif, France

    Lisa Derosa & Laurence Zitvogel

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  1. Lisa Derosa
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  2. Laurence Zitvogel
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Contributions

L.D. researched data for the article, contributed substantially to discussions of the content and wrote the initial draft. L.D. and L.Z. reviewed and/or edited the manuscript before submission.

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Correspondence to Laurence Zitvogel.

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Competing interests

L.Z. declares that she is a founder of everImmune and conducts research projects for Kaleido, Innovate Pharma and Transgene. L.D. declares no competing interests.

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Derosa, L., Zitvogel, L. Antibiotics impair immunotherapy for urothelial cancer. Nat Rev Urol 17, 605–606 (2020). https://doi.org/10.1038/s41585-020-0373-1

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