Sentinel lymph node biopsy using indocyanine green in penile cancer

Detection of positive nodes in men with moderate-risk to high-risk penile cancer and impalpable inguinal nodes is an important step in the therapeutic pathway. Detection using dynamic sentinel node biopsy with patent blue dye and radioisotope is associated with false negatives; indocyanine green might offer an alternative adjunct to improve detection rates.

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Fig. 1: Overview of current management options for patients with clinically node-negative penile cancer with the addition of ICG-guided detection2.


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O.B. and K.A. acknowledge research support from the MRC Centre for Transplantation at Kings College London, the National Institute for Health Research (NIHR) and the King’s Medical Research Trust (KMRT). K.A. acknowledges funding from the Royal College of Surgeons of England, The Urology Foundation, Coptcoat Charity, Pelican Foundation and Medtronics. A.M. is supported by the NIHR Biomedical Research Centre University College London Hospital. The authors thank M. Chand for his input on the manuscript.

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Correspondence to Asif Muneer.

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Brunckhorst, O., Ahmed, K., Alnajjar, H.M. et al. Sentinel lymph node biopsy using indocyanine green in penile cancer. Nat Rev Urol (2020).

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