Exploring the molecular basis of sexual dimorphism in bladder cancer

Bladder cancer outcomes differ between men and women. Elucidating this sexual dimorphism, genomic analyses found differing molecular subtype distributions and androgen response activities in muscle-invasive bladder cancer in men and women. Together with knowledge of cancer driver genes, biomarkers and clinical characteristics, these findings will hopefully lead to sex-based personalized research and management of bladder cancer.

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Correspondence to Shahrokh F. Shariat.

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Pradere, B., Shariat, S.F. Exploring the molecular basis of sexual dimorphism in bladder cancer. Nat Rev Urol 17, 487–488 (2020).

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