PROSTATE CANCER

Salvage therapy at biochemical recurrence of prostate cancer

No clear consensus exists for managing biochemically recurrent prostate cancer after prostatectomy. Interpretation of new data from the JCOG0401 trial warrants consideration of imaging techniques, prostate-specific antigen (PSA) levels at time of salvage radiotherapy (SRT), use of SRT ± salvage androgen deprivation therapy based on PSA levels, and the interval to biochemical failure.

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Fig. 1: Post-prostatectomy failure patterns and their optimal treatments.

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Correspondence to Nicholas G. Zaorsky.

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The authors declare no competing interests.

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Related links

AUA guidelines: https://www.auanet.org/guidelines/prostate-cancer-adjuvant-and-salvage-radiotherapy-guideline

EAU guidelines: https://uroweb.org/guideline/prostate-cancer/

NCCN guidelines: https://www.nccn.org/professionals/physician_gls/pdf/prostate.pdf

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Zaorsky, N.G., Kishan, A.U. Salvage therapy at biochemical recurrence of prostate cancer. Nat Rev Urol (2020). https://doi.org/10.1038/s41585-020-0290-3

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