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Challenging beliefs of testosterone therapy and prostate cancer

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The relationship between testosterone therapy and prostate cancer continues to challenge historic and current beliefs. A new cohort analysis revealed a ~33% reduction in prostate cancer incidence in men with increased testosterone use. The mechanisms underlying this protective effect are unclear, but these findings challenge current paradigms and warrant further investigation.

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Fig. 1: Testosterone deficiency, metabolic syndrome and prostate cancer.

References

  1. 1.

    Stavropouls, K. et al. Testosterone replacement therapy and cardiovascular risk - a closer look at additional parameters. JAMA Intern Med. 117, 1393 (2017).

  2. 2.

    Lopez, D. S. et al. Association of the extent of therapy with prostate cancer in those receiving testosterone therapy in a US commercial insurance claims database. Clin. Endocrinol. https://doi.org/10.1111/cen.14093 (2019).

  3. 3.

    Loeb, S. et al. Testosterone replacement therapy and risk of favorable and aggressive prostate cancer. J. Clin. Oncol. 35, 1430–1436 (2017).

  4. 4.

    Isbarn, H. et al. Testosterone and prostate cancer: revisiting old paradigms. Eur. Urol. 56, 48–56 (2009).

  5. 5.

    Fizazi, K. et al. Darolutamide in nonmetastatic, castration-resistant prostate vancer. N. Engl. J. Med. 380, 1235–1246 (2019).

  6. 6.

    Endogenous Hormones and Prostate Cancer Collaborative Group. Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. J. Natl Cancer Inst. 100, 170–183 (2008).

  7. 7.

    Pastuszak, A. W. et al. Testosterone therapy and prostate cancer. Transl Androl. Urol. 5, 909–920 (2016).

  8. 8.

    Ahlering, T. E. et al. Is there a role for testosterone replacement in reducing biochemical recurrence following radical prostatectomy? J. Clin. Oncol. 37, 5085–5085 (2019).

  9. 9.

    Kasper, J. S., Liu, Y. & Giovannucci, E. Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study. Int. J. Cancer 124, 1398–1403 (2009).

  10. 10.

    Lee, J. et al. Diabetes and mortality in patients with prostate cancer: a meta-analysis. Springerplus 5, 1548 (2016).

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Correspondence to Thomas E. Ahlering.

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Huynh, L.M., Ahlering, T.E. Challenging beliefs of testosterone therapy and prostate cancer. Nat Rev Urol (2019) doi:10.1038/s41585-019-0253-8

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