The MIRACLE study is a randomized, double-blind, placebo-controlled, parallel comparison phase IV study to test the effect of mirabegron in men with overactive bladder (OAB). In total, 464 men were randomized to receive 50 mg of mirabegron or placebo. The change in mean number of micturition episodes was similar between groups, but significant improvements were observed in various OAB symptom scores. No significant adverse effects were associated with mirabegron treatment.
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Shin, D. G. et al. Mirabegron as a treatment for overactive bladder symptoms in men (MIRACLE study): efficacy and safety results from a multicenter, randomized, double-blind, placebo-controlled, parallel comparison phase IV study. Neurourol. Urodyn. https://doi.org/10.1002/nau.23852 (2018)
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Fenner, A. Mirabegron MIRACLE cure for male incontinence?. Nat Rev Urol 16, 146 (2019). https://doi.org/10.1038/s41585-018-0115-9
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DOI: https://doi.org/10.1038/s41585-018-0115-9
