A recently published study has evaluated metabolism in human clear cell renal carcinomas (ccRCCs) using intraoperative [13C]glucose infusion during surgical procedures. The findings demonstrate aerobic glycolysis and repression of the Krebs cycle, confirming the existence of the Warburg effect in ccRCC tumours in vivo.
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D.R.C. researched data for the article. Both authors took part in discussion of content, wrote the article, and reviewed and edited the manuscript before submission.
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Crooks, D.R., Linehan, W.M. The Warburg effect in hominis: isotope-resolved metabolism in ccRCC. Nat Rev Urol 15, 731–732 (2018). https://doi.org/10.1038/s41585-018-0110-1
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DOI: https://doi.org/10.1038/s41585-018-0110-1
