Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Supporting sexuality and improving sexual function in transgender persons

Abstract

Sexuality is important for most cisgender as well as transgender persons and is an essential aspect of quality of life. For both the patient and their clinicians, managing gender dysphoria includes establishing a comfortable relationship with sexual health issues, which can evolve throughout the course of gender-affirming treatment. Gender-affirming endocrine treatment of transgender men and women has considerable effects on sex drive and sexual function. Gender-affirming surgery (GAS) can improve body satisfaction and ease gender dysphoria, but surgery itself can be associated with sexual sequelae associated with physical constraints of the new genitals or postsurgical pain, psychological difficulties with accepting the new body, or social aspects of having changed gender. In general, a positive body image is associated with better sexual function and satisfaction, but satisfaction with sexual function after GAS can be present despite dissatisfaction with the surgery and vice versa. Factors involved in the integrated experience of gender-affirming treatment and the way in which sexuality is perceived are complex, and supporting sexuality and improving sexual function in transgender patients is, correspondingly, multifaceted. As the transgender patient moves through their life before, during, and after gender-affirming treatment, sexuality and sexual function should be considered and maximized at all stages in order to improve quality of life.

Key points

  • Evaluation of sexual dysfunction in transgender persons is multidimensional.

  • Hormonal treatment is likely to increase sexual desire in transgender men and decrease desire in transgender women.

  • A reduction in sexual drive is not necessarily a concern, but can, in fact, be appreciated or even desirable for some patients.

  • Before initiating hormonal or surgical treatment, wishes and hopes about future sexual function should be explored.

  • Sexual problems in transgender persons can be trans specific or not. General principles in sexual medicine apply to both cisgender and transgender persons.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The biopsychosocial model.
Fig. 2: Vaginoplasty.
Fig. 3: Phalloplasty technique.
Fig. 4: Metoidoplasty.

Similar content being viewed by others

References

  1. Steensma, T. D., Kreukels, B. P. C., de Vries, A. L. C. & Cohen-Kettenis, P. T. Gender identity development in adolescence. Hormones Behav. 64, 288 (2013).

    Article  Google Scholar 

  2. Winter, S. et al. Transgender people: health at the margins of society. Lancet 388, 390–400 (2016).

    Article  PubMed  Google Scholar 

  3. Fraser, L. & Knudson, G. Past and future challenges associated with standards of care for gender transitioning clients. Psychiatr. Clin. North Am. 40, 15–27 (2017).

    Article  PubMed  Google Scholar 

  4. Richards, C. et al. Non-binary or genderqueer genders. Int. Rev. Psychiatry 28, 95–102 (2016).

    Article  PubMed  Google Scholar 

  5. Coleman, E. et al. Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int. J. Transgenderism 13, 165–232 (2012).

    Article  Google Scholar 

  6. Arcelus, J. & Bouman, W. P. (eds) in The Transgender Handbook 1–13 (Nova Science Publishers Inc., 2017).

  7. Scheim, A. I. & Bauer, G. R. Sex and gender diversity among transgender persons in Ontario, Canada: results from a respondent-driven sampling survey. J. Sex. Res. 52, 1–14 (2015).

    Article  PubMed  Google Scholar 

  8. Gomez-Gil, E. et al. Hormone-treated transsexuals report less social distress, anxiety and depression. Psychoneuroendocrinology 37, 662–670 (2012).

    Article  CAS  PubMed  Google Scholar 

  9. Arcelus, J. et al. Systematic review and meta-analysis of prevalence studies in transsexualism. Eur. Psychiatry 30, 807–815 (2015).

    Article  CAS  PubMed  Google Scholar 

  10. Collin, L., Reisner, S. L., Tangpricha, V. & Goodman, M. Prevalence of transgender depends on the “case” definition: a systematic review. J. Sex. Med. 13, 613–626 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Wiepjes, C. M. et al. The Amsterdam Cohort of Gender Dysphoria Study: trends in prevalence, treatment, and regrets (1972–2015). J. Sex. Med. 15, 582–590 (2018).

    Article  PubMed  Google Scholar 

  12. Åhs, J. W. et al. Proportion of adults in the general population of Stockholm County who want gender-affirming medical treatment. PLOS ONE https://doi.org/10.1371/journal.pone.0204606 (2018).

  13. Dhejne, C., Oberg, K., Arver, S. & Landen, M. An analysis of all applications for sex reassignment surgery in Sweden, 1960-2010: prevalence, incidence, and regrets. Arch. Sexual Behav. 43, 1535–1545 (2014).

    Article  Google Scholar 

  14. Bouman, W. P. et al. Language and trans health. Int. J. Transgenderism 18, 1–6 (2016).

    Article  Google Scholar 

  15. Fisk, N. M. Editorial: gender dysphoria syndrome — the conceptualization that liberalizes indications for total gender reorientation and implies a broadly based multi-dimensional rehabilitative regimen. West J. Med. 120, 386–391 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Cohen-Kettenis, P. T. & Pfafflin, F. The DSM diagnostic criteria for gender identity disorder in adolescents and adults. Arch. Sexual Behav. 39, 499–513 (2010).

    Article  Google Scholar 

  17. Smith, E. S., Junger, J., Derntl, B. & Habel, U. The transsexual brain - a review of findings on the neural basis of transsexualism. Neurosci. Biobehavioral Rev. 59, 251–266 (2015).

    Article  Google Scholar 

  18. Nieder, T. O. et al. Age of onset and sexual orientation in transsexual males and females. J. Sex. Med. 8, 783–791 (2011).

    Article  PubMed  Google Scholar 

  19. Nieder, T. O., Elaut, E., Richards, C. & Dekker, A. Sexual orientation of trans adults is not linked to outcome of transition-related health care, but worth asking. Int. Rev. Psychiatry 28, 103–111 (2016).

    Article  PubMed  Google Scholar 

  20. Lawrence, A. A. Sexual orientation versus age of onset as bases for typologies (subtypes) for gender identity disorder in adolescents and adults. Arch. Sexual Behav. 39, 514–545 (2010).

    Article  Google Scholar 

  21. Person, E. & Ovesey, L. The transsexual syndrome in males. II. Secondary transsexualism. Am. J. Psychother 28, 174–193 (1974).

    Article  CAS  PubMed  Google Scholar 

  22. Person, E. & Ovesey, L. The transsexual syndrome in males. I. Primary transsexualism. Am. J. Psychother 28, 4–20 (1974).

    Article  CAS  PubMed  Google Scholar 

  23. Benjamin, H. The Transsexual Phenomenon: a Scientific Report on Transsexualism and Sex Conversion in the Human Male and Female (The Julian Press Inc., NY, 1966).

    Google Scholar 

  24. Pimenoff, V. & Pfäfflin, F. Transsexualism: treatment outcome of compliant and noncompliant patients. Int. J. Transgenderism 13, 37–44 (2011).

    Article  Google Scholar 

  25. Walworth, J. R. in Gender Blending (eds Bullough, B., Bullough, V. L. & Elias, J.) 352–369 (Prometheus Books, 1997).

  26. The International Lesbian, Gay, Bisexual, Trans and Intersex Association. Annual review of the human rights situation of lesbian, gay, bisexual, trans and intersex people in Europe (ILGA, 2017).

  27. Human Rights Watch. World report (Human Rights Watch, 2017).

  28. The International Lesbian, Gay, Bisexual, Trans and Intersex Association. Sexual orientation laws in the world - overview (ILGA, 2017).

  29. Zeluf, G. et al. Health, disability and quality of life among trans people in Sweden-a web-based survey. BMC Publ. Health 16, 903 (2016).

    Article  Google Scholar 

  30. European Union Agency for Fundamental Rights. Being trans in the EU - comparative analysis of the EU LGBT survey data (FRA, 2014).

  31. World Health Organization. Sexual health, human rights and the law (WHO, 2015).

  32. McCabe, M. P. et al. Definitions of sexual dysfunctions in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015. J. Sex. Med. 13, 135–143 (2016).

    Article  PubMed  Google Scholar 

  33. Basson, R. et al. Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J. Urol. 163, 888–893 (2000).

    Article  CAS  PubMed  Google Scholar 

  34. Bitzer, J., Giraldi, A. & Pfaus, J. Sexual desire and hypoactive sexual desire disorder in women. Introduction and overview. Standard operating procedure (SOP Part 1). J. Sex. Med. 10, 36–49 (2013).

    Article  PubMed  Google Scholar 

  35. Dundon, C. M. & Rellini, A. H. More than sexual function: predictors of sexual satisfaction in a sample of women age 40–70. J. Sex. Med. 7, 896–904 (2010).

    Article  PubMed  Google Scholar 

  36. McClelland, S. I. Intimate justice: a critical analysis of sexual satisfaction. Soc. Personal Psychol. Compass 4, 663–680 (2010).

    Article  Google Scholar 

  37. Klein, G. J. & Gorzalka, B. B. Sexual functioning in transsexuals following hormone therapy and genital surgery: a review. J. Sex. Med. 6, 2922–2939 (2009).

    Article  PubMed  Google Scholar 

  38. Pfaus, J. G. Pathways of sexual desire. J. Sex. Med. 6, 1506–1533 (2009).

    Article  CAS  PubMed  Google Scholar 

  39. Pujols, Y., Seal, B. N. & Meston, C. M. The association between sexual satisfaction and body image in women. J. Sex. Med. 7, 905–916 (2010).

    Article  PubMed  Google Scholar 

  40. Nikkelen, S. W. C. & Kreukels, B. P. C. Sexual experiences in transgender people: the role of desire for gender-confirming interventions, psychological well-being, and body satisfaction. J. Sex Marital Ther. 44, 370–381 (2018).

    Article  PubMed  Google Scholar 

  41. Shepler, D. K., Smendik, J. M., Cusick, K. M. & Tucker, D. R. Predictors of sexual satisfaction for partnered lesbian, gay, and bisexual adults. Psychol. Sexual Orient. Gender Divers. 5, 25–35 (2018).

    Google Scholar 

  42. Murad, M. H. et al. Hormonal therapy and sex reassignment: a systematic review and meta-analysis of quality of life and psychosocial outcomes. Clin. Endocrinol. (Oxf) 72, 214–231 (2010).

    Article  Google Scholar 

  43. Doorduin, T. & van Berlo, W. Trans people’s experience of sexuality in the Netherlands: a pilot study. J. Homosex. 61, 654–672 (2014).

    Article  PubMed  Google Scholar 

  44. Lindroth, M., Zeluf, G., Mannheimer, L. N. & Deogan, C. Sexual health among transgender people in Sweden. Int. J. Transgend. 18, 318–327 (2018).

    Article  Google Scholar 

  45. Masters, W. H. & Johnson, V. E. Human Sexual Inadequacy (Little Brown and Co., Boston, 1970).

    Google Scholar 

  46. Kaplan, H. S. New Sex Therapy: Active Treatment of Sexual Dysfunctions (Routledge, 2013).

  47. Bancroft, J. & Janssen, E. The dual control model of male sexual response: a theoretical approach to centrally mediated erectile dysfunction. Neurosci. Biobehavioral Rev. 24, 571–579 (2000).

    Article  CAS  Google Scholar 

  48. Perelman, M. A. A new combination treatment for premature ejaculation: a sex therapist’s perspective. J. Sex. Med. 3, 1004–1012 (2006).

    Article  PubMed  Google Scholar 

  49. Toates, F. An integrative theoretical framework for understanding sexual motivation, arousal, and behavior. J. Sex. Res. 46, 168–193 (2009).

    Article  PubMed  Google Scholar 

  50. Basson, R. Human sex-response cycles. J. Sex. Marital Ther. 27, 33–43 (2001).

    Article  CAS  PubMed  Google Scholar 

  51. Brom, M., Both, S., Laan, E., Everaerd, W. & Spinhoven, P. The role of conditioning, learning and dopamine in sexual behavior: a narrative review of animal and human studies. Neurosci. Biobehavioral Rev. 38, 38–59 (2014).

    Article  CAS  Google Scholar 

  52. Brom, M. et al. The influence of emotion down-regulation on the expectation of sexual reward. Behav. Ther. 46, 379–394 (2015).

    Article  PubMed  Google Scholar 

  53. Hatzichristou, D. et al. Diagnosing sexual dysfunction in men and women: sexual history taking and the role of symptom scales and questionnaires. J. Sex. Med. 13, 1166–1182 (2016).

    Article  PubMed  Google Scholar 

  54. Raheem, O. A., Su, J. J., Wilson, J. R. & Hsieh, T. C. The association of erectile dysfunction and cardiovascular disease: a systematic critical review. Am. J. Mens Health 11, 552–563 (2017).

    Article  PubMed  Google Scholar 

  55. Lew-Starowicz, M. & Gianotten, W. L. Sexual dysfunction in patients with multiple sclerosis. Handb. Clin. Neurol. 130, 357–370 (2015).

    Article  PubMed  Google Scholar 

  56. Clayton, A. H., Croft, H. A. & Handiwala, L. Antidepressants and sexual dysfunction: mechanisms and clinical implications. Postgraduate Med. 126, 91–99 (2014).

    Article  Google Scholar 

  57. Ali, K., Raphael, J., Khan, S., Labib, M. & Duarte, R. The effects of opioids on the endocrine system: an overview. Postgrad. Med. J. 92, 677–681 (2016).

    Article  CAS  PubMed  Google Scholar 

  58. Brennan, M. J. The effect of opioid therapy on endocrine function. Am. J. Med. 126, S12–S18 (2013).

    Article  CAS  PubMed  Google Scholar 

  59. Bhasin, S., Enzlin, P., Coviello, A. & Basson, R. Sexual dysfunction in men and women with endocrine disorders. Lancet 369, 597–611 (2007).

    Article  CAS  PubMed  Google Scholar 

  60. Lewis, R. W. et al. Definitions/epidemiology/risk factors for sexual dysfunction. J. Sex. Med. 7, 1598–1607 (2010).

    Article  PubMed  Google Scholar 

  61. Haney, N. M., Alzweri, L. M. & Hellstrom, W. J. G. Male orgasmic dysfunction post-radical pelvic surgery. Sex. Med. Rev. 6, 429–437 (2018).

    Article  PubMed  Google Scholar 

  62. Haefner, H. K. et al. The impact of vulvar lichen sclerosus on sexual dysfunction. J. Women’ Health 23, 765–770 (2014).

    Article  Google Scholar 

  63. Rantell, A., Apostolidis, A., Anding, R., Kirschner-Hermanns, R. & Cardozo, L. How does lower urinary tract dysfunction affect sexual function in men and women? ICI-RS 2015-part 1. Neurourol. Urodyn. 36, 949–952 (2017).

    Article  PubMed  Google Scholar 

  64. Clayton, A. H. Sexual function and dysfunction in women. Psychiatr. Clin. North Am. 26, 673–682 (2003).

    Article  PubMed  Google Scholar 

  65. Cash, T. F. & Fleming, E. C. The impact of body image experiences: development of the body image quality of life inventory. Int. J. Eat Disord. 31, 455–460 (2002).

    Article  PubMed  Google Scholar 

  66. Simon, W. & Gagnon, J. Sexual scripts: permanence and change. Arch. Sex. Behav. 15, 97–120 (1986).

    Article  CAS  PubMed  Google Scholar 

  67. Timmermans, E. & Van den Bulck, J. Casual sexual scripts on the screen: a quantitative content analysis. Arch. Sex. Behav. 47, 1481–1496 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  68. Pomeroy, W. B. in Transsexualism and Sex Reassignment (eds Green, G. & Money, J.) 183–188 (Johns Hopkins Univ. Press,1969).

  69. Serano, J. Psychology, sexualization and trans-invalidations. 8th Ann. Philadelphia Trans-Health Conf. http://www.juliaserano.com/av/Serano-TransInvalidations.pdf (2009).

  70. Giraldi, A., Rellini, A. H., Pfaus, J. & Laan, E. Female sexual arousal disorders. J. Sex. Med. 10, 58–73 (2013).

    Article  PubMed  Google Scholar 

  71. Almeida, M. et al. Estrogens and androgens in skeletal physiology and pathophysiology. Physiol. Rev. 97, 135–187 (2017).

    Article  PubMed  Google Scholar 

  72. McEwen, B. S. & Milner, T. A. Understanding the broad influence of sex hormones and sex differences in the brain. J. Neurosci. Res. 95, 24–39 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Sansone, A., Romanelli, F., Sansone, M., Lenzi, A. & Di Luigi, L. Gynecomastia and hormones. Endocr 55, 46–53 (2017).

    Article  CAS  Google Scholar 

  74. Randall, V. A. in Hair Growth and Disorders (eds Blume-Peytavi, U., Tosti, A. & Trüeb, R. M.) 23–39 (Springer, 2008).

  75. Vita, R., Settineri, S., Liotta, M., Benvenga, S. & Trimarchi, F. Changes in hormonal and metabolic parameters in transgender subjects on cross-sex hormone therapy: a cohort study. Maturitas 107, 92–96 (2018).

    Article  CAS  PubMed  Google Scholar 

  76. Sinnecker, G. & Köhler, S. Sex hormone binding globulin response to the anabolic steroid stanozolol. Preliminary evidence for it’s suitability as a biological androgen sensitivity test. Pediatr. Res. 23, 131 (1988).

    Article  Google Scholar 

  77. Grisendi, V. et al. Age-specific reference values for serum FSH and estradiol levels throughout the reproductive period. Gynecol. Endocrinol. 30, 451–455 (2014).

    Article  CAS  PubMed  Google Scholar 

  78. Jasuja, G. K. et al. Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study. J. Gerontol. A Biol. Sci. Med. Sci. 68, 733–740 (2013).

    Article  CAS  PubMed  Google Scholar 

  79. Finkelstein, J. S. et al. Gonadal steroids and body composition, strength, and sexual function in men. N. Engl. J. Med. 369, 1011–1022 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Hembree, W. C. et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society* clinical practice guideline. J. Clin. Endocrinol. Metab. 102, 3869–3903 (2017).

    Article  PubMed  Google Scholar 

  81. Reisner, S. L. et al. Global health burden and needs of transgender populations: a review. Lancet 388, 412–436 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  82. Frisen, L. et al. Gender role behavior, sexuality, and psychosocial adaptation in women with congenital adrenal hyperplasia due to CYP21A2 deficiency. J. Clin. Endocrinol. Metab. 94, 3432–3439 (2009).

    Article  CAS  PubMed  Google Scholar 

  83. Kreukels, B. P. C. et al. Gender dysphoria and gender change in disorders of sex development/intersex conditions: results from the dsd-LIFE Study. J. Sex. Med. 15, 777–785 (2018).

    Article  PubMed  Google Scholar 

  84. Basson, R. Testosterone therapy for reduced libido in women. Ther. Adv. Endocrinol. Metab. 1, 155–164 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Corona, G. et al. Testosterone supplementation and sexual function: a meta-analysis study. J. Sex. Med. 11, 1577–1592 (2014).

    Article  CAS  PubMed  Google Scholar 

  86. Arver, S. et al. Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J. Urol. 155, 1604–1608 (1996).

    Article  CAS  PubMed  Google Scholar 

  87. Bancroft, J. The endocrinology of sexual arousal. J. Endocrinol. 186, 411–427 (2005).

    Article  CAS  PubMed  Google Scholar 

  88. Fooladi, E. et al. Testosterone improves antidepressant-emergent loss of libido in women: findings from a randomized, double-blind, placebo-controlled trial. J. Sex. Med. 11, 831–839 (2014).

    Article  CAS  PubMed  Google Scholar 

  89. Achilli, C. et al. Efficacy and safety of transdermal testosterone in postmenopausal women with hypoactive sexual desire disorder: a systematic review and meta-analysis. Fertil. Steril. 107, 475–482 (2017).

    Article  CAS  PubMed  Google Scholar 

  90. Davis, S. R. & Braunstein, G. D. Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women. J. Sex. Med. 9, 1134–1148 (2012).

    Article  CAS  PubMed  Google Scholar 

  91. Sherwin, B. B., Gelfand, M. M. & Brender, W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom. Med. 47, 339–351 (1985).

    Article  CAS  PubMed  Google Scholar 

  92. Dennerstein, L., Burrows, G. D., Wood, C. & Hyman, G. Hormones and sexuality: effect of estrogen and progestogen. Obstetr. Gynecol. 56, 316–322 (1980).

    CAS  Google Scholar 

  93. Buster, J. E. et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstetr. Gynecol. 105, 944–952 (2005).

    Article  CAS  Google Scholar 

  94. Davis, S. R. et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause 13, 387–396 (2006).

    Article  PubMed  Google Scholar 

  95. Corona, G., Isidori, A. M., Aversa, A., Burnett, A. L. & Maggi, M. Endocrinologic control of men’s sexual desire and arousal/erection. J. Sex. Med. 13, 317–337 (2016).

    Article  Google Scholar 

  96. Levin, R. J. The pharmacology of the human female orgasm - its biological and physiological backgrounds. Pharmacol. Biochem. Behav. 121, 62–70 (2014).

    Article  CAS  Google Scholar 

  97. van de Grift, T. C. et al. Effects of medical interventions on gender dysphoria and body image: a follow-up study. Psychosom. Med. 79, 815–823 (2017).

  98. Bettcher, T. M. When selves have sex: what the phenomenology of trans sexuality can teach about sexual orientation. J. Homosex. 61, 605–620 (2014).

    Article  PubMed  Google Scholar 

  99. van de Grift, T. C. et al. Body satisfaction and physical appearance in gender dysphoria. Arch. Sexual Behav. 45, 575–585 (2016).

    Article  Google Scholar 

  100. Fleming, M. Z., MacGowan, B. R., Robinson, L., Spitz, J. & Salt, P. The body image of the postoperative female-to-male transsexual. J. Consult. Clin. Psychol. 50, 461–462 (1982).

    Article  CAS  PubMed  Google Scholar 

  101. Lindgren, T. W. & Pauly, I. B. A body image scale for evaluating transsexuals. Arch. Sexual Behav. 4, 639–656 (1975).

    Article  CAS  Google Scholar 

  102. Weigert, R., Frison, E., Sessiecq, Q., Al Mutairi, K. & Casoli, V. Patient satisfaction with breasts and psychosocial, sexual, and physical well-being after breast augmentation in male-to-female transsexuals. Plast. Reconstr. Surg. 132, 1421–1429 (2013).

    Article  CAS  PubMed  Google Scholar 

  103. Veale, J. F., Lomax, T. & Clarke, D. Identity-defense model of gender-variant development. Int. J. Transgenderism 12, 125–138 (2010).

    Article  Google Scholar 

  104. Cerwenka, S. et al. Sexual behavior of gender-dysphoric individuals before gender-confirming interventions: a European multicenter study. J. Sex. Marital Ther. 40, 457–471 (2014).

    Article  PubMed  Google Scholar 

  105. Bandini, E. et al. Childhood maltreatment in subjects with male-to-female gender identity disorder. Int. J. Impot. Res. 23, 276–285 (2011).

    Article  CAS  PubMed  Google Scholar 

  106. Prunas, A. et al. Experiences of discrimination, harassment, and violence in a sample of Italian transsexuals who have undergone sex-reassignment surgery. J. Interpers. Violence 33, 2225–2240 (2016).

    Article  PubMed  Google Scholar 

  107. Gehring, D. & Knudson, G. Prevalence of childhood trauma in a clinical population of transsexual people. Int. J. Transgenderism 8, 23–30 (2005).

    Article  Google Scholar 

  108. Devor, H. Transsexualism, dissociation, and child abuse: an initial discussion based on nonclinical data. J. Psychol. Hum. Sexual. 6, 49–72 (1994).

    Article  Google Scholar 

  109. Zucker, K. J. & Kuksis, M. Gender dysphoria and sexual abuse: a case report. Child Abuse Negl. 14, 281–283 (1990).

    Article  CAS  PubMed  Google Scholar 

  110. Andersen, J. P. & Blosnich, J. Disparities in adverse childhood experiences among sexual minority and heterosexual adults: results from a multi-state probability-based sample. PLOS ONE 8, e54691 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Corliss, H. L., Cochran, S. D. & Mays, V. M. Reports of parental maltreatment during childhood in a United States population-based survey of homosexual, bisexual, and heterosexual adults. Child Abuse Negl. 26, 1165–1178 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  112. Simon, L., Zsolt, U., Fogd, D. & Czobor, P. Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: a comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. J. Behav. Ther. Exp. Psychiatry 42, 38–45 (2011).

    Article  PubMed  Google Scholar 

  113. Chen, L. P. et al. Sexual abuse and lifetime diagnosis of psychiatric disorders: systematic review and meta-analysis. Mayo Clin. Proc. 85, 618–629 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  114. Bjorkenstam, E., Burstrom, B., Vinnerljung, B. & Kosidou, K. Childhood adversity and psychiatric disorder in young adulthood: an analysis of 107,704 Swedes. J. Psychiatr. Res. 77, 67–75 (2016).

    Article  PubMed  Google Scholar 

  115. Laumann, E. O., Gagnon, J. H., Michael, R. T. & Michaels, S. The Social Organization of Sexuality: Sexual practices in the United States. (Univ. of Chicago Press, 1994).

  116. Van Houdenhove, E., Gijs, L., T’Sjoen, G. & Enzlin, P. Asexuality: a multidimensional approach. J. Sex. Res. 52, 669–678 (2015).

    Article  PubMed  Google Scholar 

  117. Auer, M. K., Fuss, J., Hohne, N., Stalla, G. K. & Sievers, C. Transgender transitioning and change of self-reported sexual orientation. PLOS ONE 9, e110016 (2014).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  118. Bockting, W., Benner, A. & Coleman, E. Gay and bisexual identity development among female-to-male transsexuals in North America: emergence of a transgender sexuality. Arch. Sexual Behav. 38, 688–701 (2009).

    Article  Google Scholar 

  119. Cerwenka, S. et al. Intimate partnerships and sexual health in gender-dysphoric individuals before the start of medical treatment. Int. J. Sexual Health 26, 52–65 (2014).

    Article  Google Scholar 

  120. Alegria, C. A. Relationship challenges and relationship maintenance activities following disclosure of transsexualism. J. Psychiatr. Mental Health Nurs. 17, 909–916 (2010).

    Article  Google Scholar 

  121. Nieschlag, E. in Fertility Control — Handbook of Experimental Pharmacology Vol. 198 (eds Habenicht, U. F. & Aitken, R.) 197–223 (Springer, Berlin, 2010).

  122. Bettocchi, C. et al. The effects of androgen depletion on human erectile function: a prospective study in male-to-female transsexuals. Int. J. Impot. Res. 16, 544–546 (2004).

    Article  CAS  PubMed  Google Scholar 

  123. Costa, R., Carmichael, P. & Colizzi, M. To treat or not to treat: puberty suppression in childhood-onset gender dysphoria. Nat. Rev. Urol. 13, 456–462 (2016).

    Article  CAS  PubMed  Google Scholar 

  124. Sorge, R. E. & Totsch, S. K. Sex differences in Pain. J. Neurosci. Res. 95, 1271–1281 (2017).

    Article  CAS  PubMed  Google Scholar 

  125. Aloisi, A. M., Ceccarelli, I., Fiorenzani, P., De Padova, A. M. & Massafra, C. Testosterone affects formalin-induced responses differently in male and female rats. Neurosci. Lett. 361, 262–264 (2004).

    Article  CAS  PubMed  Google Scholar 

  126. Ceccarelli, I., Scaramuzzino, A., Massafra, C. & Aloisi, A. M. The behavioral and neuronal effects induced by repetitive nociceptive stimulation are affected by gonadal hormones in male rats. Pain 104, 35–47 (2003).

    Article  CAS  PubMed  Google Scholar 

  127. Hau, M., Dominguez, O. A. & Evrard, H. C. Testosterone reduces responsiveness to nociceptive stimuli in a wild bird. Horm. Behav. 46, 165–170 (2004).

    Article  CAS  PubMed  Google Scholar 

  128. Ji, Y., Hu, B., Li, J. & Traub, R. J. Opposing roles of estradiol and testosterone on stress-induced visceral hypersensitivity in rats. J. Pain 19, 764–776 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  129. Schertzinger, M., Wesson-Sides, K., Parkitny, L. & Younger, J. Daily fluctuations of progesterone and testosterone are associated with fibromyalgia pain severity. J. Pain 19, 410–417 (2017).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  130. White, H. D. et al. Treatment of pain in fibromyalgia patients with testosterone gel: pharmacokinetics and clinical response. Int. Immunopharmacol. 27, 249–256 (2015).

    Article  CAS  PubMed  Google Scholar 

  131. Aloisi, A. M. et al. Cross-sex hormone administration changes pain in transsexual women and men. Pain 132 (Suppl. 1), 60–67 (2007).

    Article  CAS  Google Scholar 

  132. van de Grift, T. C. et al. A longitudinal study of motivations before and psychosexual outcomes after genital gender-confirming surgery in transmen. J. Sex. Med. 14, 1621–1628 (2017).

    Article  PubMed  Google Scholar 

  133. Morrison, S. D. et al. Long-term outcomes of rectosigmoid neocolporrhaphy in male-to-female gender reassignment surgery. Plast. Reconstructive Surg. 136, 386–394 (2015).

    Article  CAS  Google Scholar 

  134. Selvaggi, G. & Bellringer, J. Gender reassignment surgery: an overview. Nat. Rev. Urol. 8, 274–282 (2011).

    Article  PubMed  Google Scholar 

  135. LeBreton, M. et al. Genital sensory detection thresholds and patient satisfaction with vaginoplasty in male-to-female transgender women. J. Sex. Med. 14, 274–281 (2017).

    Article  Google Scholar 

  136. Selvaggi, G. et al. Genital sensitivity after sex reassignment surgery in transsexual patients. Ann. Plast. Surg. 58, 427–433 (2007).

    Article  CAS  PubMed  Google Scholar 

  137. Sigurjonsson, H., Mollermark, C., Rinder, J., Farnebo, F. & Lundgren, T. K. Long-term sensitivity and patient-reported functionality of the neoclitoris after gender reassignment surgery. J. Sex. Med. 14, 269–273 (2017).

    Article  PubMed  Google Scholar 

  138. Lawrence, A. A. Patient-reported complications and functional outcomes of male-to-female sex reassignment surgery. Arch. Sexual Behav. 35, 717–727 (2006).

    Article  Google Scholar 

  139. Morrison, S. D., Chen, M. L. & Crane, C. N. An overview of female-to-male gender-confirming surgery. Nat. Rev. Urol. 14, 486–500 (2017).

  140. Ascha, M., Massie, J. P., Morrison, S. D., Crane, C. N. & Chen, M. L. Outcomes of single stage phalloplasty by pedicled anterolateral thigh flap versus radial forearm free flap in gender confirming surgery. J. Urol. 199, 206–214 (2018).

    Article  PubMed  Google Scholar 

  141. Neuville, P. et al. Surgical outcomes of erectile implants after phalloplasty: retrospective analysis of 95 procedures. J. Sex. Med. 13, 1758–1764 (2016).

    Article  PubMed  Google Scholar 

  142. Kim, S. et al. The anatomy of forearm free flap phalloplasty for transgender surgery. Clin. Anat. 31, 145–151 (2018).

    Article  CAS  PubMed  Google Scholar 

  143. Kim, S. et al. The anatomy of abdominal flap phalloplasty for transgender surgery. Clin. Anat. 31, 181–186 (2018).

    Article  PubMed  Google Scholar 

  144. Terrell, M. et al. Anatomy of the pedicled anterolateral thigh flap for phalloplasty in transitioning-males. Clin. Anat. 31, 160–168 (2018).

    Article  PubMed  Google Scholar 

  145. Fang, R. H., Kao, Y. S., Ma, S. & Lin, J. T. Phalloplasty in female-to-male transsexuals using free radial osteocutaneous flap: a series of 22 cases. Br. J. Plast. Surg. 52, 217–222 (1999).

    Article  CAS  PubMed  Google Scholar 

  146. Jacobsson, J., Andreasson, M., Kolby, L., Elander, A. & Selvaggi, G. Patients’ priorities regarding female-to-male gender affirmation surgery of the genitalia-a pilot study of 47 patients in Sweden. J. Sex. Med. 14, 857–864 (2017).

    Article  PubMed  Google Scholar 

  147. Hage, J. J., Bout, C. A., Bloem, J. J. & Megens, J. A. Phalloplasty in female-to-male transsexuals: what do our patients ask for? Ann. Plast. Surg. 30, 323–326 (1993).

    Article  CAS  PubMed  Google Scholar 

  148. Remington, A. C. et al. Outcomes after phalloplasty: do transgender patients and multiple urethral procedures carry a higher rate of complication? Plast. Reconstr. Surg. 141, 220e–229e (2018).

    CAS  PubMed  Google Scholar 

  149. Vukadinovic, V., Stojanovic, B., Majstorovic, M. & Milosevic, A. The role of clitoral anatomy in female to male sex reassignment surgery. TheScientificWorldJournal 2014, 437378 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  150. Hage, J. J. & van Turnhout, A. A. Long-term outcome of metaidoioplasty in 70 female-to-male transsexuals. Ann. Plast. Surg. 57, 312–316 (2006).

    Article  CAS  PubMed  Google Scholar 

  151. Takamatsu, A. & Harashina, T. Labial ring flap: a new flap for metaidoioplasty in female-to-male transsexuals. J. Plast. Reconstr Aesthet. Surg. 62, 318–325 (2009).

    Article  CAS  PubMed  Google Scholar 

  152. Olson-Kennedy, J., Warus, J., Okonta, V., Belzer, M. & Clark, L. F. Chest reconstruction and chest dysphoria in transmasculine minors and young adults: comparisons of nonsurgical and postsurgical cohorts. JAMA Pediatr. 172, 431–436 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  153. van de Grift, T. C. et al. Body image in transmen: multidimensional measurement and the effects of mastectomy. J. Sex. Med. 13, 1778–1786 (2016).

    Article  PubMed  Google Scholar 

  154. Bartolucci, C. et al. Sexual quality of life in gender-dysphoric adults before genital sex reassignment surgery. J. Sex. Med. 12, 180–188 (2015).

    Article  PubMed  Google Scholar 

  155. Wålinder, J. Transsexualism: a Study of Forty-Three Cases (Akademiförlaget/Gumpert, 1967).

  156. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 5th edn (American Psychiatric Association, 2013).

  157. World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Tenth Revision (WHO, 1992).

  158. Martin, S. A. et al. Predictors of sexual dysfunction incidence and remission in men. J. Sex. Med. 11, 1136–1147 (2014).

    Article  PubMed  Google Scholar 

  159. Mitchell, K. R. et al. Sexual function in Britain: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Lancet 382, 1817–1829 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  160. Wierckx, K. et al. Sexual desire in trans persons: associations with sex reassignment treatment. J. Sex. Med. 11, 107–118 (2014).

    Article  PubMed  Google Scholar 

  161. Wierckx, K. et al. Cross-sex hormone therapy in trans persons is safe and effective at short-time follow-up: results from the European network for the investigation of gender incongruence. J. Sex. Med. 11, 1999–2011 (2014).

    Article  CAS  PubMed  Google Scholar 

  162. Elaut, E. et al. Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels. Eur. J. Endocrinol. 158, 393–399 (2008).

    Article  CAS  PubMed  Google Scholar 

  163. Weyers, S. et al. Long-term assessment of the physical, mental, and sexual health among transsexual women. J. Sex. Med. 6, 752–760 (2009).

    Article  PubMed  Google Scholar 

  164. Rosen, R. C. et al. Correlates of sexually related personal distress in women with low sexual desire. J. Sex. Med. 6, 1549–1560 (2009).

    Article  PubMed  Google Scholar 

  165. Leiblum, S. R., Koochaki, P. E., Rodenberg, C. A., Barton, I. P. & Rosen, R. C. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women’s International Study of Health and Sexuality (WISHeS). Menopause 13, 46–56 (2006).

    Article  PubMed  Google Scholar 

  166. Laumann, E. O. et al. Sexual problems among women and men aged 40–80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int. J. Impot. Res. 17, 39–57 (2005).

    Article  CAS  PubMed  Google Scholar 

  167. Bouman, M. B. et al. Patient-reported esthetic and functional outcomes of primary total laparoscopic intestinal vaginoplasty in transgender women with penoscrotal hypoplasia. J. Sex. Med. 13, 1438–1444 (2016).

    Article  PubMed  Google Scholar 

  168. Buncamper, M. E. et al. Aesthetic and functional outcomes of neovaginoplasty using penile skin in male-to-female transsexuals. J. Sex. Med. 12, 1626–1634 (2015).

    Article  PubMed  Google Scholar 

  169. Reed, H. M., Yanes, R. E., Delto, J. C., Omarzai, Y. & Imperatore, K. Non-grafted vaginal depth augmentation for transgender atresia, our experience and survey of related procedures. Aesthet. Plast. Surg. 39, 733–744 (2015).

    Article  Google Scholar 

  170. van der Sluis, W. B. et al. Long-term follow-up of transgender women after secondary intestinal vaginoplasty. J. Sex. Med. 13, 702–710 (2016).

    Article  PubMed  Google Scholar 

  171. Manrique, O. J. et al. Gender-confirmation surgery using the pedicle transverse colon flap for vaginal reconstruction: a clinical outcome and sexual function evaluation study. Plast. Reconstr. Surg. 141, 767–771 (2018).

    Article  CAS  PubMed  Google Scholar 

  172. Buncamper, M. E. et al. Penile inversion vaginoplasty with or without additional full-thickness skin graft: to graft or not to graft? Plast. Reconstr. Surg. 139, 649e–656e (2017).

    Article  CAS  PubMed  Google Scholar 

  173. ter Kuile, M. M., Brauer, M. & Laan, E. The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS): psychometric properties within a Dutch population. J. Sex. Marital Ther. 32, 289–304 (2006).

    Article  PubMed  Google Scholar 

  174. Rosen, R. et al. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J. Sex. Marital Ther. 26, 191–208 (2000).

    Article  CAS  PubMed  Google Scholar 

  175. De Cuypere, G. et al. Sexual and physical health after sex reassignment surgery. Arch. Sexual Behav. 34, 679–690 (2005).

    Article  Google Scholar 

  176. Costantino, A. et al. A prospective study on sexual function and mood in female-to-male transsexuals during testosterone administration and after sex reassignment surgery. J. Sex. Marital Ther. 39, 321–335 (2013).

    Article  PubMed  Google Scholar 

  177. Wierckx, K. et al. Sexual desire in female-to-male transsexual persons: exploration of the role of testosterone administration. Eur. J. Endocrinol. 165, 331–337 (2011).

    Article  CAS  PubMed  Google Scholar 

  178. Rowniak, S., Chesla, C., Rose, C. D. & Holzemer, W. L. Transmen: the HIV risk of gay identity. AIDS Educ. 23, 508–520 (2011).

    Article  Google Scholar 

  179. Coleman, E. Is your patient suffering from compulsive sexual behavior? Psychiatr. Ann. 22, 320–325 (1992).

    Article  Google Scholar 

  180. Kuzma, J. M. & Black, D. W. Epidemiology, prevalence, and natural history of compulsive sexual behavior. Psychiatr. Clin. North Amer. 31, 603–611 (2008).

    Article  Google Scholar 

  181. Odlaug, B. L. et al. Compulsive sexual behavior in young adults. 25, 193–200 (2013).

  182. Pastor, Z. & Chmel, R. Differential diagnostics of female “sexual” fluids: a narrative review. Int. Urogynecol. J. 29, 621–629 (2018).

    Article  PubMed  Google Scholar 

  183. Geer, J. H., Morokoff, P. & Greenwood, P. Sexual arousal in women: the development of a measurement device for vaginal blood volume. Arch. Sexual Behav. 3, 559–564 (1974).

    Article  CAS  Google Scholar 

  184. Bouchard, K. N., Chivers, M. L. & Pukall, C. F. Effects of genital response measurement device and stimulus characteristics on sexual concordance in women. J. Sex. Res. 54, 1197–1208 (2017).

    Article  PubMed  Google Scholar 

  185. Oh, S. K. et al. Brain activation in response to visually evoked sexual arousal in male-to-female transsexuals: 3.0 tesla functional magnetic resonance imaging. Kor. J. Radiol. 13, 257–264 (2012).

    Article  Google Scholar 

  186. Kim, G. W. & Jeong, G. W. Neural mechanisms underlying sexual arousal in connection with sexual hormone levels: a comparative study of the postoperative male-to-female transsexuals and premenopausal and menopausal women. Neuroreport 25, 693–700 (2014).

    CAS  PubMed  Google Scholar 

  187. Arnow, B. A. et al. Women with hypoactive sexual desire disorder compared to normal females: a functional magnetic resonance imaging study. Neuroscience 158, 484–502 (2009).

    Article  CAS  PubMed  Google Scholar 

  188. Laan, E., Everaerd, W., van der Velde, J. & Geer, J. H. Determinants of subjective experience of sexual arousal in women: feedback from genital arousal and erotic stimulus content. Psychophysiology 32, 444–451 (1995).

    Article  CAS  PubMed  Google Scholar 

  189. Hage, J. J. & Karim, R. B. Ought GIDNOS get nought? Treatment options for nontranssexual gender dysphoria. Plast. Reconstr. Surg. 105, 1222–1227 (2000).

    Article  CAS  PubMed  Google Scholar 

  190. Saleh, A., Abboudi, H., Ghazal-Aswad, M., Mayer, E. K. & Vale, J. A. Management of erectile dysfunction post-radical prostatectomy. Res. Rep. Urol. 7, 19–33 (2015).

    PubMed  PubMed Central  Google Scholar 

  191. Isidori, A. M. et al. A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review. Eur. Urol. 65, 99–112 (2014).

    Article  CAS  PubMed  Google Scholar 

  192. Brotto, L. A. et al. Psychophysiological and subjective sexual arousal to visual sexual stimuli in new women. J. Psychosomat. Obstetr. Gynecol. 26, 237–244 (2009).

    Article  Google Scholar 

  193. Schroder, M. & Carroll, R. A. New women: sexological outcomes of male-to-female gender reassignment surgery. J. Sex. Educ. Ther. 24, 137–146 (1999).

    Article  Google Scholar 

  194. Lawrence, A. A., Latty, E. M., Chivers, M. L. & Bailey, J. M. Measurement of sexual arousal in postoperative male-to-female transsexuals using vaginal photoplethysmography. Arch. Sexual Behav. 34, 135–145 (2005).

    Article  Google Scholar 

  195. Colebunders, B., Brondeel, S., D’Arpa, S., Hoebeke, P. & Monstrey, S. An update on the surgical treatment for transgender patients. Sex. Med. Rev. 5, 103–109 (2017).

    Article  PubMed  Google Scholar 

  196. Kwun Kim, S. et al. Long-term results in patients after rectosigmoid vaginoplasty. Plast. Reconstr. Surg. 112, 143–151 (2003).

    Article  PubMed  Google Scholar 

  197. Hage, J. J., Karim, R. B., Asscheman, H., Bloemena, E. & Cuesta, M. A. Unfavorable long-term results of rectosigmoid neocolpopoiesis. Plast. Reconstr. Surg. 95, 842–848; discussion 849–850 (1995).

    Article  CAS  PubMed  Google Scholar 

  198. Imbimbo, C. et al. A report from a single institute’s 14-year experience in treatment of male-to-female transsexuals. J. Sex. Med. 6, 2736–2745 (2009).

    Article  PubMed  Google Scholar 

  199. Schilt, K. & Windsor, E. The sexual habitus of transgender men: negotiating sexuality through gender. J. Homosex. 61, 732–748 (2014).

    Article  PubMed  Google Scholar 

  200. Baldassarre, M. et al. Effects of long-term high dose testosterone administration on vaginal epithelium structure and estrogen receptor-alpha and -beta expression of young women. Int. J. Impot. Res. 25, 172–177 (2013).

    Article  CAS  PubMed  Google Scholar 

  201. Kingsberg, S. A., Wysocki, S., Magnus, L. & Krychman, M. L. Vulvar and vaginal atrophy in postmenopausal women: findings from the REVIVE (REal Women’s VIews of Treatment Options for Menopausal Vaginal ChangEs) survey. J. Sex. Med. 10, 1790–1799 (2013).

    Article  Google Scholar 

  202. Kokcu, A. et al. Does surgical menopause affect sexual performance differently from natural menopause? J. Sex. Med. 12, 1407–1414 (2015).

    Article  CAS  PubMed  Google Scholar 

  203. Garaffa, G., Christopher, N. A. & Ralph, D. J. Total phallic reconstruction in female-to-male transsexuals. Eur. Urol. 57, 715–722 (2010).

    Article  PubMed  Google Scholar 

  204. Kim, S. K., Lee, K. C., Kwon, Y. S. & Cha, B. H. Phalloplasty using radial forearm osteocutaneous free flaps in female-to-male transsexuals. J. Plast. Reconstr Aesthet Surg. 62, 309–317 (2009).

    Article  PubMed  Google Scholar 

  205. Garcia, M. M., Christopher, N. A., De Luca, F., Spilotros, M. & Ralph, D. J. Overall satisfaction, sexual function and the durability of neophallus dimensions following staged female to male genital gender confirming surgery: the Institute of Urology, London, U. K. experience. Transl Androl. Urol. 3, 156–162 (2014).

    PubMed  PubMed Central  Google Scholar 

  206. Leriche, A. et al. Long-term outcome of forearm flee-flap phalloplasty in the treatment of transsexualism. BJU Int. 101, 1297–1300 (2008).

    Article  PubMed  Google Scholar 

  207. Djordjevic, M. L. et al. Metoidioplasty as a single stage sex reassignment surgery in female transsexuals: Belgrade experience. J. Sex. Med. 6, 1306–1313 (2009).

    Article  PubMed  Google Scholar 

  208. Cohanzad, S. Extensive metoidioplasty as a technique capable of creating a compatible analogue to a natural penis in female transsexuals. Aesthet. Plast. Surg. 40, 130–138 (2016).

    Article  Google Scholar 

  209. Taylor, J. F., Rosen, R. C. & Leiblum, S. R. Self-report assessment of female sexual function: psychometric evaluation of the brief index of sexual functioning for women. Arch. Sexual Behav. 23, 627–643 (1994).

    Article  CAS  Google Scholar 

  210. Wise, N. J., Frangos, E. & Komisaruk, B. R. Brain activity unique to orgasm in women: an fMRI analysis. J. Sex. Med. 14, 1380–1391 (2017).

    Article  Google Scholar 

  211. Georgiadis, J. R. et al. Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women. Eur. J. Neurosci. 24, 3305–3316 (2006).

    Article  PubMed  Google Scholar 

  212. van Netten, J. J., Georgiadis, J. R., Nieuwenburg, A. & Kortekaas, R. 8–13 hz fluctuations in rectal pressure are an objective marker of clitorally-induced orgasm in women. Arch. Sexual Behav. 37, 279–285 (2008).

    Article  Google Scholar 

  213. Eldh, J. Construction of a neovagina with preservation of the glans penis as a clitoris in male transsexuals. Plast. Reconstr. Surg. 91, 895–900; discussion 901–903 (1993).

    Article  CAS  PubMed  Google Scholar 

  214. Eldh, J., Berg, A. & Gustafsson, M. Long-term follow up after sex reassignment surgery. Scand. J. Plast. Reconstr. Surg. Hand Surg. 31, 39–45 (1997).

    Article  CAS  PubMed  Google Scholar 

  215. Rehman, J., Lazer, S., Benet, A. E., Schaefer, L. C. & Melman, A. The reported sex and surgery satisfactions of 28 postoperative male-to-female transsexual patients. Arch. Sexual Behav. 28, 71–89 (1999).

    Article  CAS  Google Scholar 

  216. Rehman, J. & Melman, A. Formation of neoclitoris from glans penis by reduction glansplasty with preservation of neurovascular bundle in male-to-female gender surgery: functional and cosmetic outcome. J. Urol. 161, 200–206 (1999).

    Article  CAS  PubMed  Google Scholar 

  217. Hage, J. J. & Karim, R. B. Sensate pedicled neoclitoroplasty for male transsexuals: Amsterdam experience in the first 60 patients. Ann. Plast. Surg. 36, 621–624 (1996).

    Article  CAS  PubMed  Google Scholar 

  218. Rubin, S. O. Sex-reassignment surgery male-to-female. Review, own results and report of a new technique using the glans penis as a pseudoclitoris. Scand J. Urol. Nephrol. Suppl. 154, 1–28 (1993).

    CAS  PubMed  Google Scholar 

  219. Hess, J., Neto, R. R., Panic, L., Rübben, H. & Senf, W. Satisfaction with male-to-female gender reassignment surgery: results of a retrospective analysis. Dtsch. Arztebl. Int. 111, 795–801 (2014).

    PubMed  PubMed Central  Google Scholar 

  220. Bentler, P. M. A typology of transsexualism: gender identity theory and data. Arch. Sexual Behav. 5, 567–584 (1976).

    Article  CAS  Google Scholar 

  221. Krege, S., Bex, A., Lummen, G. & Rubben, H. Male-to-female transsexualism: a technique, results and long-term follow-up in 66 patients. BJU Int. 88, 396–402 (2001).

    Article  CAS  PubMed  Google Scholar 

  222. Amend, B., Seibold, J., Toomey, P., Stenzl, A. & Sievert, K. D. Surgical reconstruction for male-to-female sex reassignment. Eur. Urol. 64, 141–149 (2013).

    Article  PubMed  Google Scholar 

  223. Rakic, Z., Starcevic, V., Maric, J. & Kelin, K. The outcome of sex reassignment surgery in Belgrade: 32 patients of both sexes. Arch. Sexual Behav. 25, 515–525 (1996).

    Article  CAS  Google Scholar 

  224. Giraldo, F. et al. Corona glans clitoroplasty and urethropreputial vestibuloplasty in male-to-female transsexuals: the vulval aesthetic refinement by the Andalusia Gender Team. Plast. Reconstr. Surg. 114, 1543–1550 (2004).

    Article  PubMed  Google Scholar 

  225. Freundt, I., Toolenaar, T. A., Huikeshoven, F. J., Jeekel, H. & Drogendijk, A. C. Long-term psychosexual and psychosocial performance of patients with a sigmoid neovagina. Am. J. Obstetr. Gynecol. 169, 1210–1214 (1993).

    Article  CAS  Google Scholar 

  226. Zavlin, D. et al. Male-to-female sex reassignment surgery using the combined vaginoplasty technique: satisfaction of transgender patients with aesthetic, functional, and sexual outcomes. Aesthet. Plast. Surg. 42, 178–187 (2018).

    Article  Google Scholar 

  227. Lawrence, A. A. Sexuality before and after male-to-female sex reassignment surgery. Arch. Sexual Behav. 34, 147–166 (2005).

    Article  Google Scholar 

  228. Lindemalm, G., Korlin, D. & Uddenberg, N. Long-term follow-up of “sex change” in 13 male-to-female transsexuals. Arch. Sexual Behav. 15, 187–210 (1986).

    Article  CAS  Google Scholar 

  229. Goddard, J. C. et al. Feminizing genitoplasty in adult transsexuals: early and long-term surgical results. BJU Int. 100, 607–613 (2007).

    Article  PubMed  Google Scholar 

  230. Soli, M. et al. Male to female gender reassignment: modified surgical technique for creating the neoclitoris and mons veneris. J. Sex. Med. 5, 210–216 (2008).

    Article  PubMed  Google Scholar 

  231. Lief, H. I. & Hubschman, L. Orgasm in the postoperative transsexual. Arch. Sexual Behav. 22, 145–155 (1993).

    Article  CAS  Google Scholar 

  232. Ross, M. W. & Need, J. A. Effects of adequacy of gender reassignment surgery on psychological adjustment: a follow-up of fourteen male-to-female patients. Arch. Sexual Behav. 18, 145–153 (1989).

    Article  CAS  Google Scholar 

  233. Chughtai, B. et al. A neglected gland: a review of Cowper’s gland. Int. J. Androl. 28, 74–77 (2005).

    Article  PubMed  Google Scholar 

  234. Alwaal, A., Breyer, B. N. & Lue, T. F. Normal male sexual function: emphasis on orgasm and ejaculation. Fertil. Steril. 104, 1051–1060 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  235. Thakar, R. Is the uterus a sexual organ? sexual function following hysterectomy. Sex. Med. Rev. 3, 264–278 (2015).

    Article  PubMed  Google Scholar 

  236. Smith, Y. L., Van Goozen, S. H., Kuiper, A. J. & Cohen-Kettenis, P. T. Sex reassignment: outcomes and predictors of treatment for adolescent and adult transsexuals. Psychol. Med. 35, 89–99 (2005).

    Article  PubMed  Google Scholar 

  237. Wierckx, K. et al. Quality of life and sexual health after sex reassignment surgery in transsexual men. J. Sex. Med. 8, 3379–3388 (2011).

    Article  PubMed  Google Scholar 

  238. Simonelli, C., Eleuteri, S., Petruccelli, F. & Rossi, R. Female sexual pain disorders: dyspareunia and vaginismus. Curr. Opin. Psychiatry 27, 406–412 (2014).

    Article  PubMed  Google Scholar 

  239. Horbach, S. E. et al. Outcome of vaginoplasty in male-to-female transgenders: a systematic review of surgical techniques. J. Sex. Med. 12, 1499–1512 (2015).

    Article  PubMed  Google Scholar 

  240. Elaut, E., Weyers, S., Hoebeke, P., Stockman, S. & Monstrey, S. in The Transgender Handbook (eds Arcelus, J. & Bouman, W. P.) (Nova Science Publishers Inc., 2017).

  241. Mitchell, K. R. et al. Painful sex (dyspareunia) in women: prevalence and associated factors in a British population probability survey. BJOG 124, 1689–1697 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  242. Hadj-Moussa, M., Ohl, D. A. & Kuzon, W. M. Jr. Feminizing genital gender-confirmation surgery. Sex. Med. Rev. 6, 457–468 (2018).

    Article  PubMed  Google Scholar 

  243. Frey, J. D., Poudrier, G., Chiodo, M. V. & Hazen, A. An update on genital reconstruction options for the female-to-male transgender patient: a review of the literature. Plast. Reconstr. Surg. 139, 728–737 (2017).

    Article  CAS  PubMed  Google Scholar 

  244. Hoebeke, P. B. et al. Erectile implants in female-to-male transsexuals: our experience in 129 patients. Eur. Urol. 57, 334–340 (2010).

    Article  PubMed  Google Scholar 

  245. Cohen-Kettenis, P. T. & van Goozen, S. H. Sex reassignment of adolescent transsexuals: a follow-up study. J. Am. Acad. Child Adolesc. Psychiatry 36, 263–271 (1997).

    Article  CAS  PubMed  Google Scholar 

  246. Smith, Y. L., van Goozen, S. H. & Cohen-Kettenis, P. T. Adolescents with gender identity disorder who were accepted or rejected for sex reassignment surgery: a prospective follow-up study. J. Am. Acad. Child Adolesc. Psychiatry 40, 472–481 (2001).

    Article  CAS  PubMed  Google Scholar 

  247. Lobato, M. I. et al. Follow-up of sex reassignment surgery in transsexuals: a Brazilian cohort. Arch. Sexual Behav. 35, 711–715 (2006).

    Article  Google Scholar 

  248. Cardoso da Silva, D. et al. WHOQOL-100 before and after sex reassignment surgery in brazilian male-to-female transsexual individuals. J. Sex. Med. 13, 988–993 (2016).

    Article  PubMed  Google Scholar 

  249. Johansson, A., Sundbom, E., Hojerback, T. & Bodlund, O. A five-year follow-up study of Swedish adults with gender identity disorder. Arch. Sexual Behav. 39, 1429–1437 (2010).

    Article  Google Scholar 

  250. Heylens, G., Verroken, C., De Cock, S., T’sjoen, G. & De Cuypere, G. Effects of different steps in gender reassignment therapy on psychopathology: a prospective study of persons with a gender identity disorder. J. Sex. Med. 11, 119–126 (2014).

    Article  Google Scholar 

  251. Ruppin, U. & Pfafflin, F. Long-term follow-up of adults with gender identity disorder. Arch. Sexual Behav. 44, 1321–1329 (2015).

    Article  Google Scholar 

  252. Coleman, E., Bockting, W. O. & Gooren, L. Homosexual and bisexual identity in sex-reassigned female-to-male transsexuals. Arch. Sexual Behav. 22, 37–50 (1993).

    Article  CAS  Google Scholar 

  253. Philippsohn, S. & Hartmann, U. Determinants of sexual satisfaction in a sample of German women. J. Sex. Med. 6, 1001–1010 (2009).

    Article  PubMed  Google Scholar 

  254. Lewin, B. F.-M. K., Helmius, G., Lalos, A. & Månsson, S. A. Sex in Sweden - On the Swedish Sexual Life (The National Institute of Public Health, 2000).

  255. Salvador, J. et al. Minimum 2-year follow up of sex reassignment surgery in Brazilian male-to-female transsexuals. Psychiatry Clin. Neurosci. 66, 371–372 (2012).

    Article  PubMed  Google Scholar 

  256. Castellano, E. et al. Quality of life and hormones after sex reassignment surgery. J. Endocrinol. Invest. 38, 1373–1381 (2015).

    Article  CAS  PubMed  Google Scholar 

  257. Gomez-Gil, E., Zubiaurre-Elorza, L., de Antonio, I. E., Guillamon, A. & Salamero, M. Determinants of quality of life in Spanish transsexuals attending a gender unit before genital sex reassignment surgery. Qual. Life Res. 23, 669–676 (2014).

    Article  PubMed  Google Scholar 

  258. Doornaert, M. et al. Penile reconstruction with the radial forearm flap: an update. Handchir. Mikrochir. Plast. Chir. 43, 208–214 (2011).

    Article  CAS  PubMed  Google Scholar 

  259. Terrier, J. E., Courtois, F., Ruffion, A. & Morel Journel, N. Surgical outcomes and patients’ satisfaction with suprapubic phalloplasty. J. Sex. Med. 11, 288–298 (2014).

    Article  PubMed  Google Scholar 

  260. Imborek, K. L., Graf, E. M. & McCune, K. Preventive health for transgender men and women. Semin. Reprod. Med. 35, 426–433 (2017).

    Article  PubMed  Google Scholar 

  261. Althof, S. E., Rosen, R. C., Perelman, M. A. & Rubio-Aurioles, E. Standard operating procedures for taking a sexual history. J. Sex. Med. 10, 26–35 (2013).

    Article  PubMed  Google Scholar 

  262. Kingsberg, S. A. Taking a sexual history. Obstetr. Gynecol. Clin. 33, 535–547 (2006).

    Article  Google Scholar 

  263. Brotto, L. et al. Psychological and interpersonal dimensions of sexual function and dysfunction. J. Sex. Med. 13, 538–571 (2016).

    Article  PubMed  Google Scholar 

  264. Nusbaum, M. R. & Hamilton, C. D. The proactive sexual health history. Am. Fam. Physician 66, 1705–1722 (2002).

    PubMed  Google Scholar 

  265. Armuand, G., Dhejne, C., Olofsson, J. I. & Rodriguez-Wallberg, K. A. Transgender men’s experiences of fertility preservation: a qualitative study. Hum. Reprod. 32, 383–390 (2017).

    Article  CAS  PubMed  Google Scholar 

  266. Tracy, J. K. & Junginger, J. Correlates of lesbian sexual functioning. J. Women’ Health 16, 499–509 (2007).

    Article  Google Scholar 

  267. Gabrielson, A. T., Sartor, R. A. & Hellstrom, W. J. G. The impact of thyroid disease on sexual dysfunction in men and women. Sex. Med. Rev. https://doi.org/10.1016/j.sxmr.2018.05.002 (2018).

  268. Defreyne, J. et al. Transient elevated serum prolactin in trans women is caused by cyproterone acetate treatment. LGBT Health 4, 328–336 (2017).

    Article  PubMed  Google Scholar 

  269. Sigurjonsson, H., Rinder, J., Möllermark, C., Farnebo, F. & Lundgren, T. Male to female gender reassignment surgery: surgical outcomes of consecutive patients during 14 years. JPRAS Open 6, 69–73 (2015).

    Article  Google Scholar 

  270. Al-Tamimi, M. et al. Colpectomy significantly reduces the risk of urethral fistula formation after urethral lengthening in transgender men undergoing genital gender affirming surgery. J. Urol. https://doi.org/10.1016/j.juro.2018.07.037 (2018).

  271. Gäredal, M. & Orre, C. “Trygga sammanhang gör mig kåt!”: en studie om transpersoners upplevelser och tankar om sex samt behov av kunskaper och insatser rörande sexuell hälsa (RFSL & RFSL Ungdom, 2011).

  272. Kronawitter, D. et al. Effects of transdermal testosterone or oral dydrogesterone on hypoactive sexual desire disorder in transsexual women: results of a pilot study. Eur. J. Endocrinol. 161, 363–368 (2009).

    Article  CAS  PubMed  Google Scholar 

  273. Nota, N. M. et al. Prolactin levels during short- and long-term cross-sex hormone treatment: an observational study in transgender persons. Andrologia 49, e12666 (2017).

    Article  CAS  Google Scholar 

  274. Traish, A. M., Goldstein, I. & Kim, N. N. Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction. Eur. Urol. 52, 54–70 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  275. Buvat, J. et al. Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study). J. Sex. Med. 8, 284–293 (2011).

    Article  CAS  Google Scholar 

  276. Naumova, I. & Castelo-Branco, C. Current treatment options for postmenopausal vaginal atrophy. Int. J. Women’ Health 10, 387 (2018).

    Article  Google Scholar 

  277. Unger, C. A. Update on gender-affirming treatment for the transgender woman. Semin. Reprod. Med. 35, 442–447 (2017).

    Article  PubMed  Google Scholar 

  278. Basson, R. & Gilks, T. Women’s sexual dysfunction associated with psychiatric disorders and their treatment. Womens Health https://doi.org/10.1177/1745506518762664 (2018).

  279. Bø, K. Pelvic floor muscle training in treatment of female stress urinary incontinence, pelvic organ prolapse and sexual dysfunction. World J. Urol. 30, 437–443 (2012).

    Article  PubMed  Google Scholar 

  280. Seal, B. N. & Meston, C. M. The impact of body awareness on women’s sexual health: a comprehensive review. Sex. Med. Rev. https://doi.org/10.1016/j.sxmr.2018.03.003 (2018).

  281. Giammattei, S. V. Beyond the binary: trans-negotiations in couple and family therapy. Fam. Process 54, 418–434 (2015).

    Article  PubMed  Google Scholar 

  282. Fruhauf, S., Gerger, H., Schmidt, H. M., Munder, T. & Barth, J. Efficacy of psychological interventions for sexual dysfunction: a systematic review and meta-analysis. Arch. Sexual Behav. 42, 915–933 (2013).

    Article  Google Scholar 

  283. Gunzler, C. & Berner, M. M. Efficacy of psychosocial interventions in men and women with sexual dysfunctions — a systematic review of controlled clinical trials: part 2 — the efficacy of psychosocial interventions for female sexual dysfunction. J. Sex. Med. 9, 3108–3125 (2012).

    Article  PubMed  Google Scholar 

  284. Berner, M. & Gunzler, C. Efficacy of psychosocial interventions in men and women with sexual dysfunctions — a systematic review of controlled clinical trials: part 1-the efficacy of psychosocial interventions for male sexual dysfunction. J. Sex. Med. 9, 3089–3107 (2012).

    Article  PubMed  Google Scholar 

  285. Knudson, G., Dhejne, C., Murjan, S., DeCuypere, G. & Robbins-Cherry, S. Enhancing sexual function post gender confirming surgery. Presented at the 2nd Biennial EPATH Conference. (2017).

  286. Cipolletta, S., Votadoro, R. & Faccio, E. Online support for transgender people: an analysis of forums and social networks. Health Social Care Commun. 25, 1542–1551 (2017).

    Article  Google Scholar 

  287. Ybarra, M. L., Mitchell, K. J., Palmer, N. A. & Reisner, S. L. Online social support as a buffer against online and offline peer and sexual victimization among US LGBT and non-LGBT youth. Child Abuse Negl. 39, 123–136 (2015).

    Article  PubMed  Google Scholar 

  288. Selvaggi, G., Dhejne, C., Landen, M. & Elander, A. The 2011 WPATH standards of care and penile reconstruction in female-to-male transsexual individuals. Adv. Urol. 2012, 581712 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  289. von Vogelsang, A. C., Milton, C., Ericsson, I. & Strömberg, L. ‘Wouldn’t it be easier if you continued to be a guy?’–a qualitative interview study of transsexual persons’ experiences of encounters with healthcare professionals. J. Clin. Nurs. 25, 3577–3588 (2016).

    Article  Google Scholar 

  290. Sevelius, J. “There’s no pamphlet for the kind of sex I have”: HIV-related risk factors and protective behaviors among transgender men who have sex with nontransgender men. J. Assoc. Nurses AIDS Care 20, 398–410 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  291. Dhejne, C. & Arver, S. in Handbook of Clinical Gender Medicine (eds Schenck-Gustafsson, K., DeCola, P. R., Pfaff, D. W. & Pisetsky, D. S.) (Kager, 2012).

  292. Berli, J. U. et al. What surgeons need to know about gender confirmation surgery when providing care for transgender individuals: a review. JAMA Surg. 152, 394–400 (2017).

    Article  PubMed  Google Scholar 

  293. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th edn (American Psychiatric Association, 1994).

  294. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th edn, text rev. (American Psychiatric Association, 2000).

  295. Berli, J. U., Knudson, G. & Schechter, L. Gender confirmation surgery and terminology in transgender health-reply. JAMA Surg. 152, 1091 (2017).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank plastic surgeon H. Sigurjonsson for important feedback regarding the illustrations.

Reviewer information

Natural Reviews Urology thanks S. Morrison, T. v. d. Grift and the other anonymous reviewer(s) for the peer review of this manuscript.

Author information

Authors and Affiliations

Authors

Contributions

All authors researched data for article, made substantial contributions to discussions of content, and wrote and edited the manuscript before submission.

Corresponding author

Correspondence to Mats Holmberg.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Holmberg, M., Arver, S. & Dhejne, C. Supporting sexuality and improving sexual function in transgender persons. Nat Rev Urol 16, 121–139 (2019). https://doi.org/10.1038/s41585-018-0108-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41585-018-0108-8

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing