Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Mitomycin C in the treatment of anterior urethral strictures


Anterior urethral strictures are a common urological problem and urethrotomy has limited efficacy if repeated treatment is needed. An increasing number of studies have shown that mitomycin C has potential as an adjunct to urethrotomy for improving its success rate.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Proposed mechanism of action of MMC in treatment of anterior urethral stricture.


  1. Heyns, C. F. et al. Treatment of male urethral strictures: is repeated dilation or internal urethrotomy useful? J. Urol. 160, 356–358 (1998).

    Article  CAS  Google Scholar 

  2. Van Bergen, T. et al. Improving patient outcomes following glaucoma surgery: state of the art and future perspectives. Clin. Ophthalmol. 2, 857–867 (2014).

    Article  Google Scholar 

  3. Ayyildiz, A. et al. Effect of intraurethral mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture. Int. J. Urol. 11, 1122–1126 (2004).

    Article  CAS  Google Scholar 

  4. Mazdak, H., Meshki, I. & Ghassami, F. Effect of mitomycin C on anterior urethral stricture recurrence after internal urethrotomy. Eur. Urol. 51, 1089–1092 (2007).

    Article  CAS  Google Scholar 

  5. Yakubu, A. et al. Extensive urethral stricture after using mitomycin in local anaesthetic jelly for urethral tumours. BJU Int. 83, 873–874 (1999).

    Article  CAS  Google Scholar 

  6. Kumar, S. et al. Efficacy of optical internal urethrotomy and intralesional injection of vatsala-santosh PGI tri-inject (triamcinolone, mitomycin C, and hyaluronidase) in the treatment of anterior urethral stricture. Adv. Urol. 2014, 192710 (2014).

    Article  Google Scholar 

  7. Ali, L. et al. Efficacy of mitomycin C in reducing recurrence of anterior urethral stricture after internal optical urethrotomy. Kor. J. Urol. 56, 650–655 (2015).

    Article  Google Scholar 

  8. Moradi, M. et al. Safety and efficacy of intraurethral mitomycin C hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy. J. Inj. Violence Res. 8, 75–79 (2016).

    PubMed  PubMed Central  Google Scholar 

  9. Farrell, M. R., Lawrenz, C. W. & Levine, L. A. Internal urethrotomy with intralesional mitomycin C: an effective option for endoscopic management of recurrent bulbar and bulbomembranous urethral strictures. Urology 110, 223–227 (2017).

    Article  Google Scholar 

  10. Redshaw, J. D. et al. Intralesional injection of mitomycin C at transurethral incision of bladder neck contracture may offer limited benefit: TURNS Study Group. J. Urol. 193, 587–592 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Christopher R. Chapple.

Ethics declarations

Competing interests

C.R.C. has been a consultant, adviser, grant recipient, researcher, author, speaker, meeting participant, and/or been involved in studies or trials for Astellas Pharma, Bayer Schering Parma AG, Galvani Bioelectronics (GSK), Ipsen, Lupin Limited, Pfizer, Pierre Fabre, Recordati, Sun Pharmaceutical, and Symimetics. J.J.P. and T.L.K. declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Park, J.J., Kuo, T.L. & Chapple, C.R. Mitomycin C in the treatment of anterior urethral strictures. Nat Rev Urol 15, 717–718 (2018).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing