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PROSTATE CANCER

Interfocal genomic heterogeneity uncovered

A large-scale study has for the first time reported the high degree of interfocal genomic heterogeneity in multifocal primary prostate cancer, which could inform clinical decision-making. Whole-exome sequencing in 89 tumour foci from 41 patients revealed that 76% of matched foci from the same prostatectomy specimen had no common somatic point mutations and that DNA copy number alterations were rarely shared among foci. Although a small number of mutations were shared across foci, they rarely occurred in driver genes.

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  1. Løvf, M. et al. Multifocal primary prostate cancer exhibits high degree of genomic heterogeneity. Eur. Urol. https://doi.org/10.1016/j.eururo.2018.08.009 (2018)

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Correspondence to Conor A. Bradley.

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Bradley, C.A. Interfocal genomic heterogeneity uncovered. Nat Rev Urol 15, 726 (2018). https://doi.org/10.1038/s41585-018-0098-6

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