A large-scale study has for the first time reported the high degree of interfocal genomic heterogeneity in multifocal primary prostate cancer, which could inform clinical decision-making. Whole-exome sequencing in 89 tumour foci from 41 patients revealed that 76% of matched foci from the same prostatectomy specimen had no common somatic point mutations and that DNA copy number alterations were rarely shared among foci. Although a small number of mutations were shared across foci, they rarely occurred in driver genes.
Løvf, M. et al. Multifocal primary prostate cancer exhibits high degree of genomic heterogeneity. Eur. Urol. https://doi.org/10.1016/j.eururo.2018.08.009 (2018)
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Bradley, C.A. Interfocal genomic heterogeneity uncovered. Nat Rev Urol 15, 726 (2018). https://doi.org/10.1038/s41585-018-0098-6