TESTICULAR CANCER

Risk of solid cancer after chemotherapy

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Platinum-based chemotherapy continues to be linked with the subsequent development of various solid tumours. In a large analytical study of >5,800 survivors of testicular cancer, Groot and colleagues observed statistically significant dose-dependent increases in gastrointestinal cancer incidence after platinum-based chemotherapy, providing evidence for a potential dose-dependent relationship.

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References

  1. 1.

    Groot, H. J. et al. Risk of solid cancer after treatment of testicular germ cell cancer in the platinum era. J. Clin Oncol. 36, 2504–2513 (2018).

  2. 2.

    Fung, C. et al. in CANCER: Principles & Practice of Oncology 11th edn (eds Lawrence, T. S., DeVita, V. T. Jr & Rosenberg, S. A.) (Lippincott Williams & Wilkins, in the press).

  3. 3.

    Greene, M. H. Is cisplatin a human carcinogen? J. Natl Cancer Inst. 84, 306–312 (1992).

  4. 4.

    Travis, L. B. et al. Testicular cancer survivorship: research strategies and recommendations. J. Natl Cancer Inst. 102, 1114–1130 (2010).

  5. 5.

    Wilson, C. L. et al. Renal carcinoma after childhood cancer: a report from the Childhood Cancer Survivor Study. J. Natl Cancer Inst. 105, 504–508 (2013).

  6. 6.

    Henderson, T. O. et al. Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study. Ann. Intern. Med. 156, 757–766 (2012).

  7. 7.

    Turcotte, L. M. et al. Risk of subsequent neoplasms during the fifth and sixth decades of life in the Childhood Cancer Survivor Study cohort. J. Clin. Oncol. 33, 3568–3575 (2015).

  8. 8.

    Travis, L. B. et al. Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J. Natl Cancer Inst. 97, 1354–1365 (2005).

  9. 9.

    Fung, C. et al. Solid tumors after chemotherapy or surgery for testicular nonseminoma: a population-based study. J. Clin. Oncol. 31, 3807–3814 (2013).

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Acknowledgements

L.B.T. is supported by grant R01 CA 157823 awarded by the National Cancer Institute.

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Correspondence to Lois B. Travis.

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The authors declare no competing interests.

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Fung, C., Travis, L.B. Risk of solid cancer after chemotherapy. Nat Rev Urol 15, 660–661 (2018) doi:10.1038/s41585-018-0085-y

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