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Therapy-induced small-cell disease: from mouse to man and back

With the emergence of increasingly potent androgen deprivation therapy, rates of treatment-emergent small-cell neuroendocrine prostate cancer are increasing. In a recent prospective study, Aggarwal and colleagues defined the frequency and clinical and genomic characteristics of these tumours.

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The authors declare no competing interests.

Correspondence to Robert J. Matusik.

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Fig. 1: Transdifferentiation to treatment-induced small-cell neuroendocrine prostate cancer.