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PROSTATE CANCER

Therapy-induced small-cell disease: from mouse to man and back

With the emergence of increasingly potent androgen deprivation therapy, rates of treatment-emergent small-cell neuroendocrine prostate cancer are increasing. In a recent prospective study, Aggarwal and colleagues defined the frequency and clinical and genomic characteristics of these tumours.

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Fig. 1: Transdifferentiation to treatment-induced small-cell neuroendocrine prostate cancer.

References

  1. Nuhn, P. et al. Update on systemic prostate cancer therapies: management of metastatic castration-resistant prostate cancer in the era of precision oncology. Eur. Urol. https://doi.org/10.1016/j.eururo.2018.03.028 (2018).

    Article  PubMed  Google Scholar 

  2. Davies, A. H., Beltran, H. & Zoubeidi, A. Cellular plasticity and the neuroendocrine phenotype in prostate cancer. Nat. Rev. Urol. 15, 271–286 (2018).

    Article  CAS  Google Scholar 

  3. Mosquera, J. M. et al. Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia 15, 1–10 (2013).

    Article  CAS  Google Scholar 

  4. di Sant’Agnese, P. A. Neuroendocrine differentiation in human prostatic carcinoma. Hum. Pathol. 23, 287–296 (1992).

    Article  Google Scholar 

  5. Aggarwal, R. et al. Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: a multi-institutional prospective study. J. Clin. Oncol. 36, 2492–2503 (2018).

    Article  Google Scholar 

  6. Hu, C.-D., Choo, R. & Huang, J. Neuroendocrine differentiation in prostate cancer: a mechanism of radioresistance and treatment failure. Front. Oncol. 5, 90 (2015).

    Article  Google Scholar 

  7. Bluemn, E. G. et al. Androgen receptor pathway-independent prostate cancer is sustained through FGF signaling. Cancer Cell 32, 474–489 (2017).

    Article  CAS  Google Scholar 

  8. Jin, R. J. et al. NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice. Cancer Res. 64, 5489–5495 (2004).

    Article  CAS  Google Scholar 

  9. Grabowska, M. M. et al. Mouse models of prostate cancer: picking the best model for the question. Cancer Metastasis Rev. 33, 377–397 (2014).

    Article  CAS  Google Scholar 

  10. Gupta, A. et al. Neuroendocrine differentiation in the 12T-10 transgenic prostate mouse model mimics endocrine differentiation of pancreatic beta cells. Prostate 68, 50–60 (2008).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Robert J. Matusik.

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Grabowska, M.M., Matusik, R.J. Therapy-induced small-cell disease: from mouse to man and back. Nat Rev Urol 15, 662–663 (2018). https://doi.org/10.1038/s41585-018-0084-z

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