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Genomic diversity in low-risk disease: present and future

New data have confirmed the genomic diversity of low-risk prostate cancer. Improved understanding of the heterogeneity of this disease has implications for disease management and has the potential to change treatment for patients in the future.

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References

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    Cooperberg, M. R. et al. The diverse genomic landscape of clinically low-risk prostate cancer. Eur. Urol. https://doi.org/10.1016/j.eururo.2018.05.014 (2018).

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    Fraser, M. et al. Genomic hallmarks of localized, non-indolent prostate cancer. Nature 541, 359–364 (2017).

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    Klein, E. A. et al. Molecular analysis of low grade prostate cancer using a genomic classifier of metastatic potential. J. Urol. 197, 122–128 (2017).

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    Spratt, D. E. et al. Development and validation of a novel integrated clinical-genomic risk group classification for localized prostate cancer. J. Clin. Oncol. 36, 581–590 (2018).

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    Hamdy, F. C. et al. 10-Year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N. Engl. J. Med. 375, 1415–1424 (2016).

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Correspondence to R. Jeffrey Karnes.

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Competing interests

R.J.K. declares research funding from GenomeDx and royalties related to Decipher. V.S. declares no competing interests.

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Decipher Genomic Resource Information Database: http://www.deciphergrid.com

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Fig. 1: Identification of the diverse genomic landscape of low-risk prostate cancer.