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Osteoarthritis

PDZK1 downregulation linked to mitochondrial dysfunction in OA

Nature Reviews Rheumatology volume 20, page 597 (2024)Cite this article

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Mitochondrial dysfunction downstream of mechanical overload and ageing has been associated with chondrocyte senescence in osteoarthritis (OA). A study published in Bone Research links mitochondrial dysfunction in osteoarthritic chondrocytes to loss of PDZK1 expression.

Together, these findings prompted Xiaochun Bai, Daozhang Cai and colleagues to investigate the inverse correlation between PDZK1 expression and senescence in chondrocytes. PDZK1-deficient mice had a greater number of senescent chondrocytes and exhibited more-severe OA pathology after destabilization of the medial meniscus by surgery than did their wild-type littermates. Induced expression of PDZK1 rescued the catabolic and senescent phenotype of chondrocytes subjected to mechanical overload and alleviated OA progression in mice.

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References

Original article

  • Shao, Y. et al. PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function. Bone Res. 12, 41 (2024)

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Maria Papatriantafyllou

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  1. Maria Papatriantafyllou
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Correspondence to Maria Papatriantafyllou.

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Papatriantafyllou, M. PDZK1 downregulation linked to mitochondrial dysfunction in OA. Nat Rev Rheumatol 20, 597 (2024). https://doi.org/10.1038/s41584-024-01157-x

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  • DOI: https://doi.org/10.1038/s41584-024-01157-x

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