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Advancing equity in genomic medicine for rheumatology

Nature Reviews Rheumatology volume 20, pages 595–596 (2024)Cite this article

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Increasing diversity in genomic studies is essential to advance precision medicine and health equity in rheumatic diseases. Addressing structural and logistical barriers to include underrepresented populations, particularly in Africa and Latin America, could improve our understanding of rheumatic diseases and lead to better healthcare outcomes for all.

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References

  1. Martin, A. R. et al. Clinical use of current polygenic risk scores may exacerbate health disparities. Nat. Genet. 51, 584–591 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Martin, A. R. et al. Human demographic history impacts genetic risk prediction across diverse populations. Am. J. Hum. Genet. 100, 635–649 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Tikly, M. & McGill, P. Epidemiology: the challenge of practicing rheumatology in Africa. Nat. Rev. Rheumatol. 12, 630–631 (2016).

    Article  PubMed  Google Scholar 

  4. Zhang, C., Hansen, M. E. B. & Tishkoff, S. A. Advances in integrative African genomics. Trends Genet 38, 152–168 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Mody, G. M. Rheumatoid arthritis and connective tissue disorders: sub-Saharan Africa. Baillieres Clin. Rheumatol. 9, 31–44 (1995).

    Article  CAS  PubMed  Google Scholar 

  6. Okoye, R. C. et al. HLA-D region heterogeneity in a Nigerian population. Tissue Antigens 33, 445–456 (1989).

    Article  CAS  PubMed  Google Scholar 

  7. Medina-Muñoz, S. G. et al. Demographic modeling of admixed Latin American populations from whole genomes. Am. J. Hum. Genet. 110, 1804–1816 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  8. SIGMA Type 2 Diabetes Consortium. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature 506, 97–101 (2014).

    Article  Google Scholar 

  9. SIGMA Type 2 Diabetes Consortium. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA 311, 2305–2314 (2014).

    Article  Google Scholar 

  10. Genovese, G. et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329, 841–845 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank M. Gutiérrez and P. Castro-Santos for comments. R.D.-P. is supported by the Miguel Servet (CP21/00003) contract, funded by the Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union. This work was supported by grants and support from Fondecyt grant no. 1220540, ISCIII and FEDER (PI22/00804), and GAIN Proyectos de Excelencia (IN607D2022/06) to R.D.-P.

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Authors and Affiliations

  1. Fundación Pública Galega de Medicina Xenómica, SERGAS, Grupo de Medicina Xenómica-USC, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

    Roberto Díaz-Peña

  2. Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile

    Roberto Díaz-Peña

  3. Rheumatology Unit, Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria

    Olufemi Adelowo

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  1. Roberto Díaz-Peña
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  2. Olufemi Adelowo
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Correspondence to Roberto Díaz-Peña.

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Díaz-Peña, R., Adelowo, O. Advancing equity in genomic medicine for rheumatology. Nat Rev Rheumatol 20, 595–596 (2024). https://doi.org/10.1038/s41584-024-01156-y

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