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  • Year in Review
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Spondyloarthritis in 2023

Exploring the latest advances in axial spondyloarthritis management

Nature Reviews Rheumatology volume 20, pages 79–80 (2024)Cite this article

Subjects

Studies published in 2023 emphasize the long-term efficacy and safety of novel therapeutics for both radiographic and non-radiographic axial spondyloarthritis (axSpA) and provide a consensus definition of ‘early axSpA’ for use in research studies.

Key advances

  • In an open-label extension of the phase III SELECT-AXIS 2, upadacitinib demonstrated sustained efficacy in patients with radiographic axial spondyloarthritis (axSpA) refractory to treatment with biologic DMARDs2.

  • 52-week results of the BE-MOBILE 1 and BE-MOBILE 2 studies confirmed the long-term efficacy and safety of the IL-17A–IL-17F inhibitor bimekizumab in patients with radiographic and non-radiographic axSpA3.

  • The Assessment of SpondyloArthritis international Society community has developed a consensus definition of ‘early axSpA’ to be used in research studies addressing the early stages of the disease4.

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References

  1. Ramiro, S. et al. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update. Ann. Rheum. Dis. 82, 19–34 (2023).

    Article  PubMed  Google Scholar 

  2. Baraliakos, X. et al. Efficacy and safety of upadacitinib in patients with ankylosing spondylitis refractory to biologic therapy: 1-year results from the open-label extension of a phase III study. Arthritis Res. Ther. 25, 172 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Baraliakos, X. et al. Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies. Ann. Rheum. Dis. https://doi.org/10.1136/ard-2023-224803 (2023).

    Article  PubMed  Google Scholar 

  4. Navarro-Compán, V. et al. ASAS consensus definition of early axial spondyloarthritis. Ann. Rheum. Dis. https://doi.org/10.1136/ard-2023-224232 (2023).

  5. Deodhar, A. et al. Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 400, 369–79 (2022).

    Article  CAS  PubMed  Google Scholar 

  6. European Medicines Agency. Rinvoq. EMA https://www.ema.europa.eu/en/medicines/human/EPAR/rinvoq (accessed 14 November 2023).

  7. Food and Drug Administration. Highlights of prescribing information. FDA https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/211675s012lbl.pdf (accessed 18 November 2023).

  8. Van Der Heijde, D. et al. Efficacy and safety of upadacitinib for active ankylosing spondylitis refractory to biological therapy: a double-blind, randomised, placebo-controlled phase 3 trial. Ann. Rheum. Dis. 81, 1515–1523 (2022).

    Article  PubMed  Google Scholar 

  9. Van Der Heijde, D. et al. Goodbye to the term ‘ankylosing spondylitis’, hello ‘axial spondyloarthritis’: time to embrace the ASAS defined nomenclature. Ann. Rheum. Dis. https://doi.org/10.1136/ard-2023-225185 (2023).

  10. Van Der Heijde, D. et al. Efficacy and safety of bimekizumab in axial spondyloarthritis: results of two parallel phase 3 randomised controlled trials. Ann Rheum. Dis. 82, 515–526 (2023).

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain

    Diego Benavent

  2. Idipaz, Hospital La Paz, Madrid, Spain

    Victoria Navarro-Compán

  3. Department of Rheumatology, Hospital Universitario La Paz, IdiPaz, Madrid, Spain

    Victoria Navarro-Compán

Authors
  1. Diego Benavent
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  2. Victoria Navarro-Compán
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Corresponding author

Correspondence to Victoria Navarro-Compán.

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Competing interests

D.B. declares that he has been a speaker for Eli Lilly, Janssen and UCB Pharma. V.N.-C. declares that she has been a speaker for AbbVie, Eli Lilly, Janssen, MSD, Novartis, Pfizer, and UCB Pharma; has acted as a consultant for AbbVie, Eli Lilly, Galapagos, Moonlake, MSD, Novartis, Pfizer, and UCB Pharma; and has received grant/research support from AbbVie and Novartis.

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Benavent, D., Navarro-Compán, V. Exploring the latest advances in axial spondyloarthritis management. Nat Rev Rheumatol 20, 79–80 (2024). https://doi.org/10.1038/s41584-023-01072-7

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