Rheumatoid arthritis synovium contains phenotypically and functionally heterogeneous fibroblast-like synoviocytes. Cutting-edge analyses have now defined at least four distinct states of these cells related to their location in the synovium, epigenetic imprinting and the influence of microenvironment mediators.
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G.S.F. declares that he has received a research grant from Eli Lilly. C.R.L.M. declares no competing interests.
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Machado, C.R.L., Firestein, G.S. Fibroblast multiplicity in RA: a synovial state of affairs. Nat Rev Rheumatol 19, 609–610 (2023). https://doi.org/10.1038/s41584-023-01015-2