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Rheumatoid arthritis

Fibroblast multiplicity in RA: a synovial state of affairs

Rheumatoid arthritis synovium contains phenotypically and functionally heterogeneous fibroblast-like synoviocytes. Cutting-edge analyses have now defined at least four distinct states of these cells related to their location in the synovium, epigenetic imprinting and the influence of microenvironment mediators.

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Fig. 1: Fibroblast states in the rheumatoid arthritis synovium.


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Correspondence to Gary S. Firestein.

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G.S.F. declares that he has received a research grant from Eli Lilly. C.R.L.M. declares no competing interests.

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Machado, C.R.L., Firestein, G.S. Fibroblast multiplicity in RA: a synovial state of affairs. Nat Rev Rheumatol 19, 609–610 (2023).

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