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Rheumatoid arthritis

Fibroblast multiplicity in RA: a synovial state of affairs

Nature Reviews Rheumatology volume 19, pages 609–610 (2023)Cite this article

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Rheumatoid arthritis synovium contains phenotypically and functionally heterogeneous fibroblast-like synoviocytes. Cutting-edge analyses have now defined at least four distinct states of these cells related to their location in the synovium, epigenetic imprinting and the influence of microenvironment mediators.

Refers to Smith, M. H. et al. Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis. Nat. Immunol. https://doi.org/10.1038/s41590-023-01527-9 (2023).

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Fig. 1: Fibroblast states in the rheumatoid arthritis synovium.

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Authors and Affiliations

  1. Department of Medicine, UC San Diego School of Medicine, La Jolla, CA, USA

    Camilla R. L. Machado & Gary S. Firestein

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  1. Camilla R. L. Machado
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  2. Gary S. Firestein
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Correspondence to Gary S. Firestein.

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Competing interests

G.S.F. declares that he has received a research grant from Eli Lilly. C.R.L.M. declares no competing interests.

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Machado, C.R.L., Firestein, G.S. Fibroblast multiplicity in RA: a synovial state of affairs. Nat Rev Rheumatol 19, 609–610 (2023). https://doi.org/10.1038/s41584-023-01015-2

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