IL-17 signalling regulates both protective and harmful immune responses; therefore, its complete inhibition can have adverse effects. Detailed consideration and fine-tuning of IL-17-inhibition strategies is needed to selectively regulate disease outcomes.
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I.E.A. declares that he has received speaker fees, research support and/or served on advisory boards for Novartis, Pfizer and Merck. V.K. declares no competing interests.
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Adamopoulos, I.E., Kuchroo, V. IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration. Nat Rev Rheumatol 19, 535–536 (2023). https://doi.org/10.1038/s41584-023-01004-5