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IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration

Nature Reviews Rheumatology volume 19, pages 535–536 (2023)Cite this article

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IL-17 signalling regulates both protective and harmful immune responses; therefore, its complete inhibition can have adverse effects. Detailed consideration and fine-tuning of IL-17-inhibition strategies is needed to selectively regulate disease outcomes.

Rheumatic diseases often entail musculoskeletal, skin and neuropathological components that synthesize the cardinal signs of inflammation (redness, swelling, heat, pain and loss of function). Effective therapy is therefore considered the inhibition of all the active domains of the disease while restoring the loss of function by tissue repair after injury. The pleiotropic ability of cytokines such as IL-17A and IL-17F to regulate inflammatory processes and tissue repair is being unveiled at a fast pace and is of immense therapeutic importance.

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Fig. 1: IL-17 signalling in joint inflammation and regeneration.

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Authors and Affiliations

  1. Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Iannis E. Adamopoulos

  2. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA

    Vijay Kuchroo

  3. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Vijay Kuchroo

Authors
  1. Iannis E. Adamopoulos
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  2. Vijay Kuchroo
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Correspondence to Iannis E. Adamopoulos.

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Competing interests

I.E.A. declares that he has received speaker fees, research support and/or served on advisory boards for Novartis, Pfizer and Merck. V.K. declares no competing interests.

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Adamopoulos, I.E., Kuchroo, V. IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration. Nat Rev Rheumatol 19, 535–536 (2023). https://doi.org/10.1038/s41584-023-01004-5

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  • DOI: https://doi.org/10.1038/s41584-023-01004-5

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