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Insights into juvenile myositis via engineered muscle

The pathogenesis of juvenile dermatomyositis (JDM) is complex and various evidence implicate a role for type I interferons. Could the use of a bioengineered paediatric skeletal muscle model provide insight into this disease and have potential for high throughput testing of therapeutic agents?

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This work was supported by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (project AR041215-02). The author thanks R. A. Colbert, I. Pinal-Fernandez, L. G. Rider and A. Schiffenbauer for their critical reading and input.

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Correspondence to Hanna Kim.

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H.K. is part of a clinical study at NIAMS that received grant support for under a government CRADA from Eli Lilly.

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Kim, H. Insights into juvenile myositis via engineered muscle. Nat Rev Rheumatol 19, 543–544 (2023).

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