The pathogenesis of juvenile dermatomyositis (JDM) is complex and various evidence implicate a role for type I interferons. Could the use of a bioengineered paediatric skeletal muscle model provide insight into this disease and have potential for high throughput testing of therapeutic agents?
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Acknowledgements
This work was supported by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (project AR041215-02). The author thanks R. A. Colbert, I. Pinal-Fernandez, L. G. Rider and A. Schiffenbauer for their critical reading and input.
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H.K. is part of a clinical study at NIAMS that received grant support for under a government CRADA from Eli Lilly.
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Kim, H. Insights into juvenile myositis via engineered muscle. Nat Rev Rheumatol 19, 543–544 (2023). https://doi.org/10.1038/s41584-023-01003-6
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DOI: https://doi.org/10.1038/s41584-023-01003-6
